DYNAPAR MR TABLET

💪🧠💊 Thiocolchicoside 4mg Capsule: Muscle Relaxant for Spasms, Pain & Stiffness Relief

Thiocolchicoside 4mg is a muscle relaxant with anti-inflammatory and analgesic properties, primarily used to relieve painful muscle spasms, musculoskeletal disorders, and neurological stiffness. It is derived from colchicoside, a naturally occurring compound found in the plant Colchicum autumnale. This medication is effective in treating acute and chronic muscle pain conditions, including low back pain, neck stiffness, and sciatica, especially when used in combination with NSAIDs or other pain relievers.

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🔬 Mechanism of Action

Thiocolchicoside acts on the central nervous system as a GABA-A receptor agonist and glycine receptor modulator, helping to inhibit the transmission of excessive motor signals from the spinal cord to muscles.

Its key actions include:

• Inhibiting excessive muscular contractions

• Relieving skeletal muscle spasms

• Reducing pain caused by nerve compression

• Exhibiting mild anti-inflammatory and analgesic effects

Unlike traditional muscle relaxants that cause heavy sedation, Thiocolchicoside preserves alertness and coordination, making it better tolerated during daytime use.

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📌 Indications and Uses

Thiocolchicoside 4mg capsules are prescribed for:

• Acute painful muscular spasms

• Cervical and lumbar spondylosis

• Sciatica

• Low back pain (lumbago)

• Torticollis (neck spasm)

• Post-traumatic muscle contractures

• Post-surgical musculoskeletal pain

• Neurological muscle stiffness (e.g., in multiple sclerosis – off-label)

Often, it is co-administered with NSAIDs (like Diclofenac) or analgesics to enhance pain relief.

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💊 Dosage and Administration

• Typical adult dosage: One 4mg capsule twice daily, after meals

• Duration: Short-term use (generally not more than 7 consecutive days orally)

• Not recommended for children under 16 years

Capsules should be swallowed whole with water, not chewed or opened.

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⚠️ Precautions and Warnings

• Avoid in:

  • Pregnant or breastfeeding women (contraindicated due to risk of embryo-fetal toxicity)

  • Women of childbearing potential not using contraception

  • Patients with epilepsy or seizure disorders

• Use with caution in:

  • Liver or kidney dysfunction

  • Elderly patients

• Limit use to short durations only to reduce potential toxicity risks

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🤒 Side Effects

Common side effects:

• Drowsiness (mild)

• Nausea

• Diarrhea

• Stomach discomfort

• Allergic reactions (rash, itching)

Rare/Serious:

• Seizures (especially at high doses or in predisposed individuals)

• Hepatotoxicity (with prolonged use)

• Fertility-related concerns (in high doses or long-term use – animal studies)

Immediate medical attention is needed for seizure-like symptoms, persistent abdominal pain, or signs of liver trouble (yellowing of skin or eyes).

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🔄 Drug Interactions

• May enhance effects of CNS depressants (e.g., alcohol, sedatives)

• Should not be used with antiepileptics without close medical supervision

• Often combined with NSAIDs in fixed-dose combinations

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🧊 Storage Instructions

• Store below 25°C, away from moisture and direct sunlight

• Keep in original packaging

• Keep out of reach of children

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📝 Conclusion

Thiocolchicoside 4mg capsule is a well-tolerated, effective muscle relaxant that offers fast relief from muscle spasms, back pain, and postural stiffness. When used under medical guidance for short durations, it provides excellent symptom control without heavy sedation, making it ideal for active individuals needing daytime pain relief and mobility support. Proper use and monitoring ensure safe and effective therapy.