ECOSPRIN AV 75/40 CAPSULE

💊🛡️ Atorvastatin 40mg + Aspirin 75mg Capsule: Dual Action for Heart Protection and Cholesterol Control

Atorvastatin 40mg + Aspirin 75mg is a fixed-dose combination (FDC) medication widely used for the prevention of cardiovascular events such as heart attacks (myocardial infarction), strokes, and complications in patients with high cholesterol, hypertension, diabetes, or a history of heart disease. This combination brings together two essential cardiovascular drugs with complementary actions—Atorvastatin, a statin that lowers cholesterol, and Aspirin, an antiplatelet agent that prevents clot formation.

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🔬 Mechanism of Action

🔹 Atorvastatin 40mg

• Belongs to the HMG-CoA reductase inhibitors (statins) class.

• Reduces low-density lipoprotein (LDL) cholesterol, triglycerides, and total cholesterol.

• Increases high-density lipoprotein (HDL) cholesterol.

• Slows down plaque formation in arteries and stabilizes existing plaques, reducing rupture risk.

• Offers pleiotropic effects, such as improving endothelial function and reducing inflammation.

🔹 Aspirin 75mg

• A non-steroidal anti-inflammatory drug (NSAID) with potent antiplatelet action.

• Irreversibly inhibits cyclooxygenase-1 (COX-1) in platelets, reducing thromboxane A2 synthesis.

• Prevents platelet aggregation and the formation of arterial blood clots.

• Reduces the risk of atherothrombotic events, especially in patients with known or suspected coronary artery disease.

Together, they provide synergistic protection against atherosclerotic cardiovascular disease.

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📌 Indications and Uses

This combination capsule is commonly prescribed for:

• Primary prevention of cardiovascular events in high-risk individuals (e.g., diabetics, hypertensives)

• Secondary prevention in patients with:

  • Previous myocardial infarction (heart attack)

  • Ischemic stroke

  • Angina (stable or unstable)

  • Post-angioplasty or coronary artery bypass surgery (CABG)

• Patients with hyperlipidemia and elevated clotting risk

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💊 Dosage and Administration

• Typical adult dose: One capsule once daily, preferably after the evening meal

• Should be swallowed whole with water

• Dosage may be adjusted based on lipid profile and clinical response

• Regular monitoring of lipid levels, liver function, and bleeding risk is advised

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⚠️ Precautions and Warnings

• Use with caution in:

  • Liver disease or history of liver enzyme elevation (Atorvastatin)

  • Gastric ulcers or bleeding disorders (Aspirin)

  • Patients with asthma, kidney disease, or diabetes

• Avoid in:

  • Pregnancy and breastfeeding

  • Active peptic ulcer disease

  • Known hypersensitivity to either component

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🤒 Side Effects

Atorvastatin-related:

• Muscle pain or weakness (myopathy, rhabdomyolysis – rare)

• Liver enzyme elevation

• Headache, abdominal discomfort

Aspirin-related:

• Gastric irritation, ulcers, or bleeding

• Heartburn

• Easy bruising or bleeding

Seek immediate medical attention if signs of unusual bleeding, dark stools, yellowing of skin/eyes, or severe muscle pain appear.

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🔄 Drug Interactions

• Avoid with other anticoagulants (e.g., warfarin, DOACs) unless prescribed—risk of bleeding

• Limit alcohol intake—can increase liver side effects

• Monitor if used with NSAIDs, corticosteroids, or antifungals

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🧊 Storage Instructions

• Store in a cool, dry place (15–25°C)

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

The Atorvastatin 40mg + Aspirin 75mg capsule offers a comprehensive cardiovascular protection strategy by combining cholesterol reduction with antiplatelet action. Ideal for patients at high risk or with a history of heart or vascular disease, this dual therapy helps prevent life-threatening events and supports long-term heart health when used with regular monitoring and lifestyle changes.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.