ELIQUIS 5 TABLET

🩸💊 Apixaban 5mg Tablet: Next-Generation Anticoagulant for Stroke and Clot Prevention

Apixaban 5mg is a direct oral anticoagulant (DOAC) that belongs to the class of Factor Xa inhibitors. It is widely prescribed to prevent and treat blood clots, reduce the risk of stroke, and manage conditions like atrial fibrillation, deep vein thrombosis (DVT), and pulmonary embolism (PE). Unlike traditional anticoagulants like warfarin, Apixaban does not require regular blood monitoring and has fewer dietary restrictions, making it a preferred option for long-term clot prevention.

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🔬 Mechanism of Action

Apixaban selectively and reversibly inhibits Factor Xa, a key enzyme in the coagulation cascade. By blocking Factor Xa:

• It prevents the conversion of prothrombin to thrombin

• This reduces fibrin clot formation

• Helps maintain smooth blood flow, especially in patients at high risk of thromboembolic events

Importantly, it works without affecting platelet function, offering targeted anticoagulation.

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📌 Indications and Uses

Apixaban 5mg is approved for:

🔹 Stroke Prevention in Atrial Fibrillation

• Reduces risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation

🔹 Treatment of DVT and PE

• Effective for treating acute deep vein thrombosis or pulmonary embolism

🔹 Prevention of Recurrent DVT/PE

• Continued use lowers risk of repeat clot formation

🔹 Post-Surgical DVT Prophylaxis

• In patients undergoing hip or knee replacement surgery

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💊 Dosage and Administration

• Standard adult dose: 5mg twice daily

• Reduced dose (2.5mg twice daily) may be used in patients who meet two of the following:

  • Age ≥80 years

  • Body weight ≤60 kg

  • Serum creatinine ≥1.5 mg/dL

Take with or without food. If a dose is missed, take it as soon as remembered, but do not double up.

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⚠️ Precautions and Warnings

• Increased bleeding risk: avoid if there is active bleeding or conditions with high bleeding tendency

• Not for use in mechanical heart valves

• Use with caution in:

  • Severe liver or kidney disease

  • Patients undergoing spinal/epidural procedures (risk of hematoma)

• Avoid abrupt discontinuation—can increase risk of thrombotic events

In case of overdose or emergency bleeding, andexanet alfa may be used as a reversal agent (where available).

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🤒 Side Effects

Common:

• Easy bruising

• Nosebleeds

• Minor bleeding (gums, cuts)

Serious:

• Major gastrointestinal or intracranial bleeding

• Allergic reactions (rash, swelling, difficulty breathing)

• Anemia

Seek immediate medical attention for prolonged bleeding, dark stools, or unusual fatigue.

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🔄 Drug Interactions

• Caution with:

  • Antiplatelet agents (aspirin, clopidogrel)

  • NSAIDs (ibuprofen, naproxen)

  • CYP3A4 and P-gp inhibitors (e.g., ketoconazole, ritonavir)

  • Inducers (e.g., rifampin, carbamazepine) may reduce efficacy

Avoid combining with other anticoagulants unless directed by a physician.

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🧊 Storage Instructions

• Store at room temperature (15–30°C)

• Protect from moisture and heat

• Keep away from children and pets

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📝 Conclusion

Apixaban 5mg tablet is a modern, effective oral anticoagulant offering stroke prevention and blood clot treatment with a more convenient and predictable profile than older drugs like warfarin. Its fixed dosing, no need for INR monitoring, and proven efficacy make it a leading choice for safe and long-term anticoagulation in appropriate patients. Regular check-ups and proper adherence are key to ensuring optimal protection.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.