ENCORATE CHRONO 500 TABLET

🧠⚡💊 Sodium Valproate 333mg + Valproic Acid 145mg Tablet: High-Strength Control for Epilepsy & Mood Disorders

The combination of Sodium Valproate 333mg and Valproic Acid 145mg delivers a total valproate equivalent of 500mg, making it a high-strength formulation ideal for the treatment of moderate to severe epilepsy, bipolar disorder, and migraine prophylaxis. This dual-action formulation provides both immediate and sustained release, offering superior control over seizures and mood fluctuations in various neurological and psychiatric conditions.

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🔬 Mechanism of Action

Sodium Valproate and Valproic Acid work synergistically to increase the concentration of gamma-aminobutyric acid (GABA) in the brain—a key inhibitory neurotransmitter responsible for calming neuronal activity. The mechanism includes:

• Enhancement of GABA synthesis

• Inhibition of GABA breakdown

• Blocking of voltage-gated sodium and T-type calcium channels, stabilizing nerve activity

This combination exerts a broad-spectrum antiepileptic effect and also works as a central mood stabilizer.

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📌 Indications and Uses

This 500mg total valproate tablet is used in:

• Epilepsy:

  • Generalized tonic-clonic seizures

  • Absence seizures

  • Myoclonic seizures

  • Partial (focal) seizures

  • Mixed seizure types

• Bipolar disorder:

  • Acute manic episodes

  • Long-term mood stabilization

• Migraine prophylaxis

• Impulse control disorders, aggression, or behavioral issues in neurological conditions (off-label)

It is suitable for adults and adolescents who need higher therapeutic doses in a convenient single-tablet form.

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💊 Dosage and Administration

• Starting dose: Usually 10–15 mg/kg/day; titrated to 30–60 mg/kg/day

• For bipolar disorder: 750–1500 mg/day, adjusted by response

• Migraine prevention: 500–1000 mg/day

• Tablet should be taken after meals to minimize gastrointestinal discomfort

• Doses should be divided throughout the day unless using an extended-release form

👩‍⚕️ Always follow physician’s dosage recommendation, especially during titration.

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⚠️ Precautions and Warnings

• Liver function must be closely monitored, especially in the first 6 months

• Contraindicated in:

  • Liver disease

  • Known urea cycle disorders

  • Pregnancy, due to high teratogenic risk (e.g., neural tube defects, cognitive delays)

• Use cautiously in:

  • Children under 2 years

  • Patients with renal impairment

  • Individuals with bleeding disorders

Regular monitoring of liver enzymes, complete blood count, and serum ammonia levels is recommended.

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🤒 Side Effects

Common:

• Nausea, indigestion

• Drowsiness, tremor

• Weight gain

• Temporary hair loss

Serious (seek immediate medical attention):

• Hepatotoxicity

• Pancreatitis

• Severe allergic reactions

• Thrombocytopenia or bleeding

• Hyperammonemic encephalopathy

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🔄 Drug Interactions

• May potentiate effects of Lamotrigine, Phenytoin, Phenobarbital

• May increase bleeding risk when taken with anticoagulants

• Avoid alcohol and other CNS depressants

• Can affect hormonal contraceptives and should be discussed with a healthcare provider

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🧊 Storage Instructions

• Store at 15–30°C, in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

Sodium Valproate 333mg + Valproic Acid 145mg offers robust, high-dose therapy for managing complex seizure disorders and mood instability. Its broad-spectrum action, dual pharmacokinetics, and effectiveness in multiple indications make it a go-to medication in neurological and psychiatric care. With careful monitoring and adherence, it offers long-term control and improved quality of life.