ESOKEM L CAPSULE

Description

🌐 Dual Relief Capsule for Reflux & Motility Disorders

(Esomeprazole 40mg + Levosulpiride 75mg)

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🔍 What Is This Medication Combination?

The Esomeprazole 40mg + Levosulpiride 75mg capsule is a fixed-dose combination used to treat gastroesophageal reflux disease (GERD), functional dyspepsia, acid reflux, and other related gastrointestinal motility disorders.

Components:

1. Esomeprazole 40mg

   • A proton pump inhibitor (PPI) that suppresses stomach acid production by irreversibly blocking the H⁺/K⁺ ATPase pump in gastric parietal cells.

   • Treats acid reflux, GERD, peptic ulcers, and prevents NSAID-induced gastritis.

2. Levosulpiride 75mg

   • A prokinetic and antipsychotic agent belonging to the substituted benzamide class. It acts as a dopamine D₂ receptor antagonist in the gastrointestinal tract, enhancing gut motility and relieving symptoms like nausea, bloating, early satiety, and abdominal discomfort.

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💊 How to Use This Capsule

• Dosage: Typically once or twice daily, before meals (usually 30–60 minutes prior to eating).

• Administration: Swallow the capsule whole with water; do not chew or crush.

• Duration: Treatment duration is usually 2–8 weeks, depending on clinical response.

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⚠️ Common Side Effects

Mostly mild and often temporary:

• Esomeprazole-related:

  • Headache

  • Abdominal pain

  • Diarrhea or constipation

  • Flatulence

• Levosulpiride-related:

  • Drowsiness

  • Dizziness

  • Increased appetite or weight gain

  • Mild galactorrhea (milk secretion)

  • Menstrual irregularities

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🚨 Serious Side Effects (Seek Immediate Medical Attention)

• Levosulpiride-related:

  • Extrapyramidal symptoms (tremors, rigidity, restlessness)

  • Hyperprolactinemia (prolonged use may cause hormonal imbalances)

  • Gynecomastia in men

  • Depression or mood changes

• Esomeprazole-related:

  • Severe allergic reaction (rash, swelling, difficulty breathing)

  • Low magnesium levels (muscle cramps, seizures)

  • Bone fractures with long-term use

  • Persistent diarrhea (possible Clostridioides difficile infection)

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🔍 Monitoring & Follow-Up

• Initial Monitoring: Track symptom relief (heartburn, regurgitation, bloating).

• Lab Monitoring:

  • Serum magnesium, especially in long-term users

  • Prolactin levels if on Levosulpiride for extended periods

  • Liver function tests (rare hepatotoxicity)

• Cardiac Monitoring: ECG if patient is on other QT-prolonging medications

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⚠️ Warnings & Precautions

• Avoid in elderly without regular monitoring due to sedation and movement-related risks.

• Not for long-term psychiatric use unless under specialist care.

• Avoid alcohol: It may increase sedative effects and worsen reflux.

• Pregnancy & Breastfeeding: Use only if clearly needed; levosulpiride may not be safe during lactation.

• CNS effects: Levosulpiride may cause drowsiness—avoid operating machinery.

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✅ Summary

The Esomeprazole 40mg + Levosulpiride 75mg capsule provides dual therapeutic benefits for patients suffering from acid reflux with delayed gastric emptying or functional dyspepsia. While Esomeprazole reduces stomach acid, Levosulpiride enhances gastrointestinal motility, improving symptoms such as bloating, fullness, and regurgitation. It is generally well tolerated but should be used with caution in certain populations due to hormonal and neurological side effects. Regular monitoring and short-term use under medical guidance are essential for safe and effective treatment.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.