FAXICAD 200 TABLET

🌿💊 Rifaximin 200mg Tablet: A Gut-Specific Antibiotic with Targeted Action

Rifaximin 200mg is a broad-spectrum, non-absorbable antibiotic primarily used to treat gastrointestinal infections. Known for its minimal systemic absorption, it acts locally in the gut, making it ideal for conditions like traveler’s diarrhea, irritable bowel syndrome (IBS), and hepatic encephalopathy. Its excellent safety profile and targeted action have made it a valuable therapy in managing gut-related bacterial imbalances.

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🔬 Mechanism of Action

Rifaximin works by inhibiting bacterial RNA synthesis, specifically targeting the β-subunit of bacterial DNA-dependent RNA polymerase. This interference halts bacterial protein production, ultimately leading to bacterial death. Since it remains largely within the gastrointestinal tract, it:

• Minimizes systemic side effects

• Targets harmful bacteria in the gut

• Maintains much of the beneficial microbiota balance

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📌 Indications and Uses

Rifaximin 200mg is mainly indicated for:

• Traveler’s Diarrhea: Caused by Escherichia coli in adults and children over 12 years.

• Irritable Bowel Syndrome with Diarrhea (IBS-D): To reduce bloating, gas, and loose stools.

• Hepatic Encephalopathy (HE): Helps reduce the recurrence of HE episodes by decreasing ammonia-producing gut bacteria (used in combination with lactulose).

• Small Intestinal Bacterial Overgrowth (SIBO): Off-label but increasingly used for symptom control.

It is not effective for diarrhea caused by invasive bacteria such as Salmonella, Shigella, or Campylobacter.

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💊 Dosage and Administration

• Traveler’s Diarrhea: 200mg taken three times daily for 3 days.

• IBS-D: 550mg (higher dose) three times daily for 14 days (200mg may be prescribed off-label in milder cases).

• Hepatic Encephalopathy: 550mg twice daily for prevention (note: 200mg tablets may be adjusted in certain regimens).

• Should be taken with or without food, as directed by the physician.

💡 The 200mg dosage is more common in acute infections, whereas higher doses are used for chronic or long-term conditions.

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⚠️ Precautions and Warnings

• Not for systemic infections: Due to low absorption, it’s not effective for infections outside the GI tract.

• Liver impairment: Use with caution in patients with severe liver dysfunction.

• Pregnancy and lactation: Use only if clearly needed and prescribed.

• Antibiotic resistance: Avoid unnecessary or prolonged use to reduce risk of resistance.

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🤒 Side Effects

Rifaximin is well-tolerated by most people. Common side effects may include:

• Nausea

• Flatulence

• Abdominal pain

• Headache

• Increased liver enzymes (rarely)

Serious but rare:

• Hypersensitivity reactions (rash, itching, swelling)

• C. difficile-associated diarrhea (very rare)

Seek medical attention if severe abdominal symptoms, rash, or signs of allergy occur.

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🔄 Drug Interactions

• Minimal systemic absorption means low risk of drug interactions.

• However, always inform your doctor if you’re taking:

  • Cyclosporine

  • Warfarin

  • Other antibiotics or laxatives

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🧊 Storage Instructions

• Store at room temperature (15–30°C)

• Keep in a dry, cool place, away from moisture and sunlight

• Keep out of reach of children

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📝 Conclusion

Rifaximin 200mg is a highly effective, gut-focused antibiotic with broad utility in treating and preventing intestinal infections and liver-related cognitive dysfunction. Its minimal absorption makes it a safe and targeted option with a low risk of systemic side effects. However, it should always be used under medical guidance to prevent misuse and ensure therapeutic success.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.