Description

💊 Overview

This tablet is a dual-action painkiller that combines the anti-inflammatory effects of diclofenac with the pain-relieving and fever-reducing properties of paracetamol. It is commonly prescribed for musculoskeletal pain, dental pain, joint inflammation, and fever with pain.

🧪 Ingredients & Mechanism of Action

Diclofenac Sodium (50 mg) – A non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation, swelling, and pain by inhibiting cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis.
Paracetamol (325 mg) – An analgesic and antipyretic that raises the pain threshold and reduces fever by acting on the hypothalamic heat-regulating center.

Combined Action:
This combination provides faster and more effective pain relief with reduced gastrointestinal side effects compared to diclofenac alone.

✅ Indications / Uses

Headache, migraine
Dental pain and post-dental surgery pain
Joint pain: osteoarthritis, rheumatoid arthritis
Muscular pain, sprains, and strains
Menstrual cramps
Back pain, sciatica
Fever with body aches

📋 How to Use

Typical Dose: 1 tablet two to three times daily, after food.
Route: Oral, with a full glass of water.
Duration: Use for short-term relief unless advised otherwise.
Do not exceed the maximum daily dose of paracetamol (4,000 mg/day) or diclofenac.

⚠️ Common Side Effects

Gastric discomfort or acidity
Nausea or vomiting
Headache
Dizziness
Drowsiness
Indigestion or bloating

These side effects are generally mild and short-lived.

🚨 Serious Side Effects (Seek Immediate Help)

Gastrointestinal bleeding (black stools, vomiting blood)
Liver damage (yellowing of eyes/skin, dark urine, fatigue)
Allergic reaction (rash, itching, swelling, difficulty breathing)
Kidney dysfunction (reduced urine output, swelling in legs)
Severe abdominal pain or persistent nausea
High blood pressure or cardiac symptoms (rare, but possible with long-term use)

🔍 Monitoring & Follow-Up

Liver Function Tests (LFTs): Recommended if used regularly
Renal Function Tests (KFTs): In elderly or long-term users
Blood Pressure Monitoring: If used long term, especially in hypertensive patients
GI Monitoring: Watch for signs of ulcers or bleeding

⚠️ Warnings & Precautions

Liver Disease: Use with caution; paracetamol is hepatotoxic in overdose
Kidney Impairment: NSAIDs can worsen renal function
Stomach Ulcers or GI Bleeding: Avoid or use under strict supervision
Pregnancy & Breastfeeding: Avoid in late pregnancy; use only under medical advice
Alcohol Use: Increases risk of liver damage — avoid
Elderly Patients: Increased risk of GI and kidney side effects
Drug Interactions: Avoid using with other NSAIDs, blood thinners, or other paracetamol-containing medications

📝 Summary

The Diclofenac 50mg + Paracetamol 325mg tablet is a widely used, fast-acting, and effective treatment for mild to moderate pain and inflammation. It offers the benefits of reduced swelling, relief from pain, and control of fever in a single dose. However, due to potential liver, kidney, and gastrointestinal risks, it should be used for short-term relief under medical supervision. Regular monitoring is essential for safe long-term use.

Consult your doctor before use and never self-medicate.