FOLITROL TABLET

Description

🧠❤️🔬 Advanced Neurovascular & Hematologic Support: Active B-Complex Powerhouse

The L-Methylfolate 5mg + Calcium + Methylcobalamin 1500mcg + Pyridoxal-5-Phosphate 3mg tablet is a high-potency, bioavailable formulation designed to support neurological health, cardiovascular function, and optimal red blood cell production. This advanced combination provides active forms of B vitamins—crucial for methylation processes, homocysteine regulation, and nerve repair—making it especially effective for individuals with genetic polymorphisms (like MTHFR mutations), neuropathy, and vascular or cognitive disorders.

---

🔬 Composition and Mechanism of Action

1. L-Methylfolate (5mg):
   This is the active, bioavailable form of folate (Vitamin B9) that bypasses the need for conversion by the MTHFR enzyme. It plays a central role in:

   • DNA synthesis and repair

   • Neurotransmitter production (serotonin, dopamine, norepinephrine)

   • Homocysteine metabolism, reducing cardiovascular risk
     L-Methylfolate is especially beneficial for individuals with impaired folate metabolism and is superior to synthetic folic acid in bioefficacy.

2. Calcium:
   While primarily known for its role in bone health, calcium in this formulation supports:

   • Cell signaling

   • Nerve impulse transmission

   • Muscle contraction and vascular tone
     It also enhances the stability and absorption of folate in the body.

3. Methylcobalamin (1500mcg):
   The neurologically active form of Vitamin B12, essential for:

   • Myelin sheath maintenance and nerve repair

   • Red blood cell formation

   • DNA synthesis and methylation
     Methylcobalamin is crucial for treating B12 deficiency-related neuropathies, anemia, and cognitive decline.

4. Pyridoxal-5-Phosphate (3mg):
   The coenzymatically active form of Vitamin B6, involved in:

   • Neurotransmitter synthesis (serotonin, GABA)

   • Amino acid metabolism

   • Lowering homocysteine levels in synergy with B9 and B12
     P5P supports mental health, cognitive function, and cardiovascular protection.

---

⚖️ Benefits of the Combination

This tablet provides:

• Comprehensive neurovascular protection

• Enhanced methylation capacity and detoxification

• Effective management of diabetic and peripheral neuropathy

• Mood and cognitive support, particularly in depressive disorders

• Reduced homocysteine levels, lowering risk for stroke and heart disease

• Support for anemia prevention through red blood cell synthesis

---

💊 Dosage and Administration

• Usually taken as one tablet daily, with or without food.

• Dosage may be tailored based on clinical condition or physician’s direction.

---

⚠️ Side Effects and Precautions

Generally well-tolerated. Possible side effects include:

• Mild gastrointestinal symptoms (nausea, upset stomach)

• Rare allergic reactions

Precautions:

• Use cautiously in individuals with renal disease or on anticoagulants

• Monitor B12 and homocysteine levels during long-term use

• Ensure diagnosis of B12 deficiency before supplementing folate to avoid masking symptoms

---

🩺 Clinical Applications

This formulation is beneficial for:

• MTHFR gene mutation carriers

• Peripheral or diabetic neuropathy

• Depression and cognitive impairment

• Megaloblastic anemia

• Cardiovascular disease risk reduction

• Pregnancy planning and prenatal care (when higher folate levels are needed)

---

📌 Conclusion

The L-Methylfolate + Calcium + Methylcobalamin + Pyridoxal-5-Phosphate tablet delivers active, bioavailable B vitamins that work synergistically to support the nervous system, cardiovascular health, and red blood cell production. It’s an ideal choice for individuals with genetic enzyme deficiencies, neuropathy, or those requiring advanced nutritional support for mental and metabolic health.