Description
💊 Itraconazole 200mg Capsule – Complete Guide
What is Itraconazole?
Itraconazole is a triazole antifungal medication used to treat a variety of fungal infections in the body. It works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes, ultimately killing or stopping the growth of fungi.
Composition / Ingredients
Each Itraconazole 200mg capsule typically contains:
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Itraconazole USP 200mg (active ingredient)
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Inactive ingredients such as sugar spheres, hypromellose, polyethylene glycol, titanium dioxide, and gelatin (depending on the brand)
Itraconazole is lipophilic and requires an acidic environment for proper absorption, so it’s often taken with food to increase bioavailability.
How to Use
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Dosage: Take as prescribed by your healthcare provider. Typically, it’s taken once or twice daily with a full meal.
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Swallow whole: Do not crush or chew the capsule.
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Duration depends on the type and severity of infection:
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Dermatophytosis (skin infections): 1–2 weeks
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Onychomycosis (nail fungus): Up to 12 weeks
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Systemic fungal infections: As per doctor’s guidance
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Important: Continue full course even if symptoms improve early.
Common Side Effects
Most are mild and temporary:
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Nausea or vomiting
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Diarrhea or constipation
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Headache
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Abdominal pain
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Rash or skin itching
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Dizziness
Serious Side Effects (Seek Immediate Medical Attention)
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Liver toxicity: Yellowing of skin/eyes, dark urine, severe fatigue
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Heart failure: Shortness of breath, swelling in legs, rapid weight gain
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Severe allergic reaction: Hives, difficulty breathing, facial swelling
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Neuropathy: Tingling, numbness, or burning in hands/feet
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Hearing loss (rare)
Monitoring & Follow-Up
Patients taking Itraconazole long-term or at high doses should be regularly monitored:
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Liver function tests (LFTs): Baseline and periodically
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Kidney function tests
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Drug levels (Itraconazole serum levels): Especially in patients with poor response or toxicity
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Cardiac monitoring (in patients with history of heart disease)
Warnings & Precautions
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Not for use in congestive heart failure patients unless no alternative
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Avoid in pregnancy (unless life-threatening infection)
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Drug interactions: Potent inhibitor of CYP3A4 – can dangerously raise levels of other drugs (e.g., statins, benzodiazepines, certain antihistamines)
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Avoid antacids or proton pump inhibitors (e.g., omeprazole) within 2 hours of dose as they reduce absorption
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Use with caution in liver or kidney disease
Summary
Itraconazole 200mg capsules are an effective treatment for a wide range of fungal infections, particularly those involving the skin, nails, and internal organs. While generally well-tolerated, patients should be aware of potential liver toxicity, drug interactions, and the need for regular monitoring during prolonged use. Always follow your healthcare provider’s instructions, and never self-medicate with antifungals.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult your healthcare provider for personalized recommendations.
