GALVUS 50 TABLET

🩸💊🛡️ Vildagliptin 50mg Tablet: DPP-4 Inhibitor for Type 2 Diabetes Control

Vildagliptin 50mg is an oral antidiabetic medication belonging to the class of Dipeptidyl Peptidase-4 (DPP-4) inhibitors, used in the management of Type 2 Diabetes Mellitus (T2DM). It is designed to improve blood sugar control in adults by enhancing the body’s natural incretin system, which helps regulate insulin release and reduce glucose production. Vildagliptin can be used alone or in combination with other antidiabetic agents such as metformin, sulfonylureas, or insulin.

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🔬 Mechanism of Action

Vildagliptin works by inhibiting the DPP-4 enzyme, which is responsible for breaking down incretin hormones (GLP-1 and GIP). These hormones:

• Stimulate insulin secretion from pancreatic beta cells in response to meals

• Suppress glucagon secretion from alpha cells

• Slow gastric emptying and reduce postprandial glucose spikes

By preserving incretin levels, Vildagliptin leads to glucose-dependent insulin secretion, helping lower blood sugar without causing significant hypoglycemia.

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📌 Indications and Uses

Vildagliptin 50mg is indicated for:

• Type 2 Diabetes Mellitus (T2DM) in adults:

  • As monotherapy (in patients intolerant to metformin)

  • In dual therapy with:

    • Metformin (most common)

    • Sulfonylurea

    • Thiazolidinediones

    • Insulin

• Especially suitable for patients who:

  • Are overweight

  • Have mild to moderate renal impairment

  • Are at risk of hypoglycemia from other agents

It is not recommended for Type 1 diabetes or diabetic ketoacidosis.

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💊 Dosage and Administration

• Standard dose: 50mg once or twice daily, depending on combination therapy

  • 50mg once daily when used with sulfonylureas

  • 50mg twice daily with metformin or insulin

• Can be taken with or without food

• Dosage adjustment may be needed in patients with renal impairment

Always follow physician guidance on dosing schedule and combination therapy.

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⚠️ Precautions and Warnings

• Not for use in Type 1 diabetes or insulin-dependent cases

• Caution in:

  • Moderate to severe renal impairment

  • Liver dysfunction (monitor liver enzymes regularly)

  • Patients with a history of pancreatitis

• Not recommended in pregnancy or breastfeeding due to limited safety data

Routine monitoring of HbA1c, liver enzymes, and renal function is advised during treatment.

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🤒 Side Effects

Common:

• Headache

• Dizziness

• Upper respiratory tract infections

• Constipation

Less common/serious:

• Elevated liver enzymes

• Pancreatitis (rare but serious)

• Allergic skin reactions (rash, itching)

• Joint pain or muscle stiffness

Seek medical help if you experience severe abdominal pain, jaundice, or signs of allergy.

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🔄 Drug Interactions

• Generally well tolerated with:

  • Metformin, sulfonylureas, insulin, glitazones

• No significant interaction with CYP450 enzymes, so low risk with most other drugs

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🧊 Storage Instructions

• Store at 15–30°C, protected from moisture and light

• Keep out of reach of children

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📝 Conclusion

Vildagliptin 50mg tablet is a well-tolerated, effective DPP-4 inhibitor that improves post-meal and fasting glucose levels in people with Type 2 Diabetes. With its low risk of hypoglycemia, weight-neutral profile, and ease of combination with other oral drugs, it is a versatile and safe choice for long-term glycemic control.