GALVUS MET 50/850 TABLET

Description

🩺 Vildagliptin 50mg + Metformin 850mg Tablet: A Complete Overview for Type 2 Diabetes Management

Introduction:
Vildagliptin 50mg + Metformin 850mg is an oral antidiabetic combination medication used in the treatment of Type 2 Diabetes Mellitus (T2DM). It is designed for patients who cannot control their blood sugar levels through diet, exercise, and monotherapy alone. This fixed-dose combination enhances glycemic control by targeting different aspects of blood glucose regulation.

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Ingredients & Mechanism of Action:

• Vildagliptin (50mg): A DPP-4 (Dipeptidyl Peptidase-4) inhibitor, Vildagliptin increases levels of incretin hormones (GLP-1 and GIP), which stimulate insulin release and suppress glucagon secretion when glucose levels are high.

• Metformin (850mg): A biguanide, Metformin works primarily by reducing hepatic glucose production and improving insulin sensitivity, thereby lowering blood sugar levels without causing weight gain or significant hypoglycemia.

Together, they offer a synergistic effect for better glycemic control compared to either drug used alone.

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Uses:

• Primarily prescribed for Type 2 Diabetes Mellitus in adults.

• Suitable when monotherapy with Metformin or Vildagliptin alone is insufficient.

• Helps lower HbA1c levels, reducing the risk of diabetes-related complications.

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Dosage and Administration:

• Commonly taken twice daily, with meals to reduce gastrointestinal side effects.

• Dosage may vary depending on the patient’s renal function, age, and response to treatment.

• Should be taken as per physician’s guidance; not for use in Type 1 diabetes or diabetic ketoacidosis.

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Side Effects:
Common side effects include:

• Gastrointestinal disturbances: Nausea, diarrhea, abdominal discomfort (mostly due to Metformin).

• Hypoglycemia: Rare when used alone, but risk increases with other antidiabetics.

• Headache or dizziness

• Nasopharyngitis and upper respiratory tract infections (linked to Vildagliptin).

Serious but rare side effects:

• Lactic acidosis (a medical emergency linked to Metformin, especially in renal impairment)

• Pancreatitis

• Liver enzyme elevation

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Precautions and Warnings:

• Renal function: Must be monitored regularly, especially in elderly patients.

• Hepatic impairment: Use with caution; liver function tests are recommended.

• Cardiovascular risk: Should be used cautiously in patients with heart failure.

• Alcohol intake: Should be limited due to the risk of lactic acidosis.

• Pregnancy & lactation: Not generally recommended; consult healthcare providers.

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Drug Interactions:

• May interact with diuretics, corticosteroids, beta-blockers, and contrast dyes used in imaging.

• Caution when combined with other glucose-lowering medications (e.g., insulin, sulfonylureas).

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Storage & Handling:

• Store in a cool, dry place, away from direct sunlight.

• Keep out of reach of children.

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Conclusion:
Vildagliptin 50mg + Metformin 850mg is a valuable dual-therapy option for adults with Type 2 Diabetes who require enhanced glycemic control. With proper monitoring and adherence, it significantly helps in maintaining target blood glucose levels and improving long-term health outcomes. As always, it should be used under medical supervision with routine monitoring of kidney and liver function.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.