GLUCI INJECTION

🧪 Calcium Gluconate 50mg + Calcium Lactobionate 87.5mg Injection – Clinical Overview 💉

Introduction:
Calcium Gluconate 50mg combined with Calcium Lactobionate 87.5mg is an intravenous (IV) formulation used to address acute calcium deficiencies and related conditions. This combination provides a bioavailable source of calcium, essential for various physiological functions, including muscle contraction, nerve transmission, and bone health.

🧬 Pharmacological Profile

• Calcium Gluconate: A calcium salt used to treat or prevent calcium deficiencies.

• Calcium Lactobionate: A calcium salt of lactic acid, enhancing calcium absorption and bioavailability.

Mechanism of Action:
Upon administration, both calcium salts dissociate to release calcium ions into the bloodstream, correcting hypocalcemia and supporting cellular functions.

🩺 Clinical Indications

This combination is indicated for:

• Acute Hypocalcemia: Rapid correction of low calcium levels.

• Hypocalcemic Tetany: Muscle spasms due to calcium deficiency.

• Neonatal Hypocalcemia: Calcium supplementation in newborns.

• Calcium Supplementation in Renal Dialysis: To counteract calcium loss during dialysis.

💊 Dosage and Administration

• Adult Dosage: Typically, 1–2 vials (10–20 mL) administered intravenously over 10–20 minutes.

• Pediatric Dosage: Dosage is weight-based; consult pediatric dosing guidelines.

• Administration: Administer slowly via IV route; avoid rapid infusion to reduce the risk of adverse reactions.

⚠️ Warnings and Precautions

• Hypercalcemia: Avoid in patients with elevated calcium levels.

• Renal Impairment: Use cautiously in patients with kidney dysfunction; monitor calcium levels closely.

• Cardiac Monitoring: In patients receiving cardiac glycosides, monitor for arrhythmias due to potential calcium-sensitizing effects.

• Extravasation Risk: Avoid extravasation during IV administration to prevent tissue necrosis.

🚫 Contraindications

• Hypercalcemia: Do not administer in cases of high blood calcium levels.

• Allergy: Hypersensitivity to calcium salts or any component of the formulation.

• Neonates with Ceftriaxone: Concurrent use with ceftriaxone in neonates can lead to precipitate formation.

🤒 Common Side Effects

• Injection Site Reactions: Pain, redness, or swelling at the injection site.

• Systemic Effects: Flushing, nausea, vomiting, or constipation.

• Cardiovascular: Bradycardia or hypotension with rapid infusion.

🧾 Storage and Handling

• Storage: Store at room temperature, away from light and moisture.

• Preparation: Reconstitute as per manufacturer’s instructions before administration.

• Stability: Use reconstituted solution promptly; do not store for extended periods.

✅ Safety Advice

• Monitoring: Regularly monitor serum calcium levels during therapy.

• Administration Rate: Infuse slowly to minimize the risk of adverse reactions.

• Drug Interactions: Avoid concurrent use with certain medications like ceftriaxone in neonates.

• Patient Education: Inform patients about potential side effects and the importance of adhering to prescribed dosages.

📝 Conclusion

Calcium Gluconate 50mg combined with Calcium Lactobionate 87.5mg injection is a valuable therapeutic option for addressing acute calcium deficiencies. Proper administration and monitoring are essential to ensure efficacy and minimize risks. Healthcare providers should assess individual patient needs and adjust treatment protocols accordingly.