Description
Product Description
Glimepiride 2mg + Metformin 500mg is a combination oral anti-diabetic medication used to treat Type 2 Diabetes Mellitus (T2DM). This formulation is designed for patients whose blood sugar levels are not adequately controlled by Metformin alone or lifestyle changes such as diet and exercise. This fixed-dose combination targets both insulin resistance and inadequate insulin secretion, offering a more comprehensive glycemic control.
Active Ingredients and Mechanism of Action
1. Glimepiride (2mg)
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Class: Sulfonylurea
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Mechanism: Stimulates pancreatic beta cells to secrete more insulin.
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Effect: Helps reduce postprandial (after meal) blood glucose levels quickly.
2. Metformin (500mg)
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Class: Biguanide
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Mechanism: Decreases glucose production in the liver and increases insulin sensitivity in muscle tissues.
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Effect: Helps lower fasting blood glucose and improves the body’s response to insulin.
Together, Glimepiride and Metformin work in synergy—Glimepiride boosts insulin secretion, while Metformin enhances its effectiveness and prevents the liver from producing excess glucose.
How to Use
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Dosage: Usually prescribed once or twice daily, depending on your blood sugar levels and physician’s advice.
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Timing: Take with meals—preferably breakfast and/or dinner—to minimize gastrointestinal discomfort and reduce the risk of hypoglycemia.
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Swallow whole: Do not crush or chew the tablet.
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Monitoring: Regular blood glucose monitoring is essential to adjust dosage and track effectiveness.
Tip: Maintain a balanced diet, engage in physical activity, and follow your doctor’s advice for the best results.
Common and Serious Side Effects
Common Side Effects
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Metformin-related: Nausea, abdominal pain, bloating, diarrhea, metallic taste
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Glimepiride-related: Dizziness, mild weight gain, low blood sugar (especially if meals are skipped)
Serious Side Effects (Seek Immediate Medical Attention)
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Severe Hypoglycemia: Symptoms include confusion, blurred vision, trembling, sweating, or fainting.
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Lactic Acidosis (Rare, from Metformin): May present with extreme fatigue, muscle pain, difficulty breathing, or cold sensations in the limbs.
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Allergic Reactions: Rash, itching, swelling, and difficulty breathing
Always inform your healthcare provider if side effects persist or worsen.
Precautions and Warnings
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Not suitable for: Type 1 diabetes, diabetic ketoacidosis, or patients with severe kidney or liver disease
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Alcohol warning: Avoid alcohol as it may increase the risk of lactic acidosis and hypoglycemia
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Medication interactions: Inform your doctor of all medications and supplements you are taking
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Monitoring: Periodic tests for blood sugar, kidney function, and vitamin B12 levels may be required
Conclusion
Glimepiride 2mg + Metformin 500mg is a clinically proven dual-action therapy for effective management of Type 2 Diabetes. It helps improve glycemic control, reduce the risk of complications, and supports better long-term outcomes when combined with a healthy lifestyle and regular monitoring.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
