Description
Product Description
Glimepiride 1mg + Metformin 500mg is a widely used oral anti-diabetic medication prescribed for patients with Type 2 Diabetes Mellitus (T2DM). It combines two different classes of drugs, each working through distinct mechanisms to effectively lower blood sugar levels. This fixed-dose combination is ideal for patients who do not achieve adequate glycemic control with Metformin alone or who require stepwise intensification of therapy.
Active Ingredients and Their Actions
1. Glimepiride (1 mg)
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Drug Class: Sulfonylurea
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Action: Stimulates pancreatic beta cells to release insulin.
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Benefits: Rapidly lowers blood glucose levels, especially effective in managing postprandial (after-meal) sugar spikes.
2. Metformin (500 mg)
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Drug Class: Biguanide
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Action: Reduces glucose production in the liver and increases insulin sensitivity in muscles.
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Benefits: Does not cause weight gain, reduces cardiovascular risk, and is typically the first-line drug in diabetes management.
These agents work synergistically to provide sustained control over both fasting and postprandial blood glucose levels.
How to Use
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Dosage: As advised by your physician. Commonly taken once or twice daily with meals.
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Administration: Swallow the tablet whole with a glass of water, preferably with breakfast or dinner to reduce gastrointestinal side effects.
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Diet and Exercise: Continue to follow a diabetic-friendly diet and regular physical activity plan as recommended.
Important: Do not skip meals while on this medication, as it may increase the risk of low blood sugar (hypoglycemia).
Possible Side Effects
Common Side Effects
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Metformin-related: Diarrhea, nausea, stomach upset, metallic taste in the mouth.
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Glimepiride-related: Mild hypoglycemia (low blood sugar), dizziness, or slight weight gain.
Serious Side Effects (Rare but Severe)
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Lactic Acidosis (Metformin): A rare but serious complication. Symptoms include rapid breathing, severe weakness, abdominal pain, and cold feeling.
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Severe Hypoglycemia (Glimepiride): Signs include sweating, shakiness, headache, confusion, or visual disturbances.
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Allergic Reactions: Rash, itching, swelling of the face or throat, or difficulty breathing.
Seek immediate medical attention if any severe or unusual symptoms occur.
Precautions and Warnings
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Not recommended for Type 1 Diabetes or in patients with diabetic ketoacidosis.
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Use with caution in patients with kidney or liver dysfunction.
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Avoid alcohol, as it may increase the risk of lactic acidosis and hypoglycemia.
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Regular monitoring of blood glucose and kidney function is essential.
Inform your doctor about all medications, including over-the-counter drugs and supplements, to prevent interactions.
Conclusion
Glimepiride 1mg + Metformin 500mg offers a convenient and effective way to manage blood sugar levels in Type 2 Diabetes. It provides dual benefits by enhancing insulin secretion and reducing insulin resistance. Always use under medical supervision and combine with healthy lifestyle habits for best results.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
