Description
💊 Dapagliflozin 10mg + Vildagliptin 100mg Tablets
Dual Pathway Diabetes Management – Precision Glucose Control Without Complexity
Overview
Dapagliflozin 10mg + Vildagliptin 100mg is a dual oral anti-diabetic combination designed to manage Type 2 Diabetes Mellitus in adults. This fixed-dose combination unites two distinct classes of glucose-lowering agents—SGLT2 inhibitor and DPP-4 inhibitor—providing a synergistic effect on blood sugar control. It is prescribed when blood glucose is not adequately managed with monotherapy or dual therapy with metformin.
Pharmacological Class
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Dapagliflozin – SGLT2 (Sodium-Glucose Co-Transporter-2) Inhibitor
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Vildagliptin – DPP-4 (Dipeptidyl Peptidase-4) Inhibitor
Mechanism of Action
1. Dapagliflozin (10mg)
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Inhibits glucose reabsorption in the kidneys by blocking SGLT2.
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Promotes urinary glucose excretion, thereby lowering blood glucose levels.
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Offers weight reduction and mild blood pressure lowering benefits.
2. Vildagliptin (100mg)
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Inhibits the DPP-4 enzyme, enhancing the body’s own incretin hormones.
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Increases insulin secretion and decreases glucagon levels, particularly after meals.
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Improves beta-cell responsiveness and postprandial glucose control.
Together, these drugs provide comprehensive glycemic regulation—targeting fasting and post-meal glucose levels.
Indications
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Adults with Type 2 Diabetes Mellitus
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Inadequate glycemic control on monotherapy (e.g., metformin)
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Suitable as part of a triple therapy regimen (with or without metformin)
How to Use
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Dosage: Typically taken once daily, as prescribed by a physician.
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Route: Oral
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Timing: Can be taken with or without food, preferably at the same time each day.
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Swallow tablet whole with water. Do not crush or chew.
Patients are advised to stay well hydrated, especially while on dapagliflozin.
Benefits
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Dual-action therapy for comprehensive blood sugar management
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Lowers both fasting and postprandial glucose
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Minimal risk of hypoglycemia when used alone
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Helps with weight loss and blood pressure reduction
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Convenient once-daily dosing
Side Effects
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Dapagliflozin: Urinary tract or genital infections, increased urination, dehydration
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Vildagliptin: Headache, sore throat, dizziness, rare liver enzyme elevation
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Rare but serious: Ketoacidosis, pancreatitis, allergic reactions
Patients should be aware of symptoms like abdominal pain, unusual tiredness, or urinary discomfort and report them promptly.
Precautions
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Not for use in Type 1 Diabetes or diabetic ketoacidosis
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Use cautiously in patients with kidney or liver impairment
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Regular monitoring of renal function, liver enzymes, and HbA1c is recommended
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Not recommended during pregnancy or breastfeeding
Storage
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Store in a cool, dry place below 30°C
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Keep out of reach of children
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Protect from light and moisture
When to Contact a Doctor
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Signs of genital or urinary infection
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Severe abdominal pain or nausea
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Symptoms of dehydration (dry mouth, dizziness, fatigue)
Conclusion
The combination of Dapagliflozin 10mg + Vildagliptin 100mg offers a balanced and effective approach to managing Type 2 Diabetes Mellitus, especially in patients requiring dual therapy. Its once-daily dosing and multiple metabolic benefits make it a convenient option in long-term diabetes care.
