Overview
This combination of Dapagliflozin 10mg + Metformin 1000mg + Vildagliptin 100mg is a powerful oral anti-diabetic medication used to manage Type 2 Diabetes Mellitus. It works by targeting multiple pathways involved in high blood sugar levels, helping improve glycemic control in adults who are inadequately controlled by diet, exercise, and single or dual drug therapy.
Composition and Class
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Dapagliflozin (10 mg) – SGLT2 Inhibitor
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Metformin (1000 mg) – Biguanide
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Vildagliptin (100 mg) – DPP-4 Inhibitor
Together, they form a Triple Combination Therapy offering comprehensive blood sugar control.
Mechanism of Action
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Dapagliflozin lowers blood glucose by promoting glucose excretion through the urine via inhibition of sodium-glucose co-transporter-2 (SGLT2) in the kidneys.
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Metformin decreases glucose production in the liver and improves insulin sensitivity.
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Vildagliptin increases levels of incretin hormones, which improve insulin release and reduce glucagon levels after meals.
Indications
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Type 2 Diabetes Mellitus in adults
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Inadequate glycemic control with metformin and other oral antidiabetics
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As an adjunct to diet and exercise
How to Use
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Dosage: As prescribed by your doctor. Typically once or twice daily depending on your medical condition.
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Route: Oral
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Timing: Usually taken with meals to reduce the risk of gastrointestinal side effects.
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Do not crush or chew the tablet; swallow it whole with water.
Benefits
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Targets three different mechanisms for better blood sugar control
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May aid in weight loss (due to dapagliflozin)
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Cardiovascular and renal benefits associated with dapagliflozin
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Reduced postprandial and fasting glucose levels
Precautions
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Monitor kidney function, liver enzymes, and blood glucose levels regularly.
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Not for use in Type 1 diabetes or diabetic ketoacidosis.
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Use caution in elderly patients and those with kidney or liver impairment.
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Possible side effects: urinary tract infections, nausea, hypoglycemia (especially with sulfonylureas), diarrhea, and dehydration.
Storage
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Store in a cool, dry place below 30°C.
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Keep out of reach of children.
When to Consult a Doctor
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Symptoms of low blood sugar (sweating, dizziness, rapid heartbeat)
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Signs of a urinary tract infection
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Severe abdominal pain or persistent vomiting
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If you’re pregnant, planning pregnancy, or breastfeeding
Conclusion
Dapagliflozin + Metformin + Vildagliptin is an effective triple therapy for patients with uncontrolled Type 2 Diabetes. Regular use along with diet, exercise, and periodic medical follow-up can significantly improve quality of life and reduce long-term complications.
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