GLYREE M2 TABLET

🩸💊🛡️ Glimepiride 2mg + Metformin 500mg Tablet: A Dual-Action Powerhouse for Type 2 Diabetes Management

Glimepiride 2mg + Metformin 500mg is a widely prescribed oral antidiabetic combination therapy used in the management of Type 2 Diabetes Mellitus (T2DM). It combines two medications with complementary mechanisms of action—Glimepiride, a sulfonylurea, and Metformin, a biguanide—to help control high blood sugar levels, especially when lifestyle changes and monotherapy are insufficient.

This fixed-dose combination is effective, affordable, and commonly used as first-line or step-up therapy in diabetic patients, especially in those with obesity, insulin resistance, or poorly controlled HbA1c levels.

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🔬 Mechanism of Action

This combination addresses diabetes from two fronts:

🔹 Glimepiride (2mg) – Sulfonylurea

• Stimulates the pancreas to release more insulin

• Works on beta cells of the pancreas

• Reduces post-meal blood sugar spikes

🔹 Metformin (500mg) – Biguanide

• Reduces glucose production by the liver (hepatic gluconeogenesis)

• Improves insulin sensitivity in muscle and fat tissues

• Delays intestinal absorption of glucose

• Does not cause hypoglycemia when used alone

Together, they help in fasting and postprandial blood glucose control with improved insulin action and pancreatic support.

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📌 Indications and Uses

This combination is indicated for:

• Type 2 Diabetes Mellitus in adults

• Patients uncontrolled on Metformin alone

• Initial therapy in newly diagnosed diabetes (if HbA1c is significantly high)

• Those with insulin resistance, obesity, or metabolic syndrome

It’s not used for Type 1 diabetes or diabetic ketoacidosis.

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💊 Dosage and Administration

• Usual dose: One tablet once or twice daily with meals (usually breakfast and/or dinner)

• Start with low doses and titrate gradually under medical supervision

• Always take with food to reduce gastrointestinal side effects of Metformin and prevent hypoglycemia from Glimepiride

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⚠️ Precautions and Warnings

• Monitor blood glucose levels regularly

• Use cautiously in:

  • Elderly patients

  • Those with kidney or liver disease

  • Heart failure or hypoxic conditions (Metformin risk of lactic acidosis)

• Avoid alcohol to prevent lactic acidosis

• Not safe in pregnancy without medical supervision

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🤒 Side Effects

Common:

• Hypoglycemia (from Glimepiride, especially if skipping meals)

• Nausea, vomiting, metallic taste

• Diarrhea or abdominal discomfort (from Metformin)

• Headache, dizziness

Serious/Rare:

• Lactic acidosis (a medical emergency; symptoms: muscle pain, fatigue, fast breathing)

• Allergic skin reactions

• Liver enzyme elevation (rare)

Report persistent hypoglycemia, fatigue, or abdominal pain to a doctor immediately.

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🔄 Drug Interactions

• Increased risk of hypoglycemia with:

  • Insulin

  • Beta-blockers

  • NSAIDs

• Avoid drugs affecting kidney function (e.g., contrast dyes, aminoglycosides)

• Alcohol and corticosteroids may impair blood glucose control

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🧊 Storage Instructions

• Store at 15–30°C, away from heat and moisture

• Keep in original packaging

• Out of reach of children and pets

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📝 Conclusion

Glimepiride 2mg + Metformin 500mg is a synergistic antidiabetic combination that effectively lowers blood sugar while targeting insulin resistance and pancreatic insufficiency. With proper diet, exercise, and regular monitoring, this medication helps maintain long-term glycemic control, reduce the risk of complications, and improve the quality of life in patients with Type 2 diabetes.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.