HEPAMERZ INJECTION 10ML

🧬 What is L-Ornithine-L-Aspartate (LOLA)?
L-Ornithine-L-Aspartate is a compound made of two amino acids—ornithine and aspartic acid—used primarily in the treatment of hepatic encephalopathy (HE), a neuropsychiatric complication associated with liver dysfunction. LOLA works by enhancing the detoxification of ammonia, a substance that accumulates in the blood due to liver impairment. The injectable form of LOLA offers rapid therapeutic action, especially in acute or hospitalized settings.

💉 Formulation and Administration
LOLA injection is typically available in sterile, aqueous solutions for intravenous (IV) administration. It is often given as a slow infusion diluted in compatible IV fluids such as saline or dextrose. Dosage varies depending on the severity of hepatic dysfunction and the patient’s clinical response but usually ranges between 20–40 grams per day in divided doses.

⚙️ Mechanism of Action
LOLA works through two main biochemical pathways:

1. Urea Cycle Enhancement: Ornithine activates enzymes in the urea cycle, especially in the liver, helping convert toxic ammonia into urea, which can be safely excreted via the kidneys.

2. Glutamine Synthesis: Aspartate promotes the formation of glutamine in peripheral tissues like muscle and brain, where ammonia is neutralized by incorporating it into glutamine molecules.

Together, these actions significantly lower systemic ammonia levels and alleviate the neurological symptoms of hepatic encephalopathy.

🩺 Clinical Uses
The primary indication for LOLA injection is:

• Hepatic Encephalopathy (acute and chronic forms)

It may also be used as supportive therapy in:

• Cirrhosis-related complications

• Hepatic coma

• Hyperammonemia of various etiologies

Its injectable form is particularly useful for patients unable to take oral medications or during emergencies requiring rapid ammonia reduction.

📊 Efficacy and Benefits
Clinical studies have shown that LOLA injection can:

• Reduce serum ammonia levels quickly and effectively

• Improve mental status and cognitive function in HE patients

• Lower the risk of progression to coma in acute episodes

• Potentially improve liver function markers over time

It is often used alongside other treatments such as lactulose, rifaximin, and nutritional support.

⚠️ Side Effects and Precautions
While generally well tolerated, LOLA may cause:

• Nausea or vomiting

• Abdominal discomfort

• Hypersensitivity reactions (rare)

• Electrolyte imbalances with prolonged use

Caution is advised in patients with renal impairment, as the urea produced requires renal excretion.

📦 Storage and Handling
LOLA injection should be stored in a cool, dry place, away from direct sunlight. It must be handled using sterile technique, and opened vials should be used immediately to maintain sterility and effectiveness.

🔍 Summary
L-Ornithine-L-Aspartate injection is a valuable tool in managing hepatic encephalopathy and related conditions. Its dual action on ammonia detoxification pathways provides both symptomatic relief and biochemical improvement. The injectable form offers a fast-acting, reliable option in both acute care and long-term hepatic support settings.