INBEC TABLET

🧬💊🛡️ Triple Shield Against HIV: Abacavir 600mg + Dolutegravir 50mg + Lamivudine 300mg Tablet

The combination of Abacavir 600mg + Dolutegravir 50mg + Lamivudine 300mg is a fixed-dose antiretroviral (ARV) tablet used in the treatment of HIV-1 infection. It is part of the Highly Active Antiretroviral Therapy (HAART) regimen and offers a complete, once-daily, single-pill regimen, making it highly effective for maintaining viral suppression, improving adherence, and enhancing quality of life in people living with HIV.

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🧪 Composition and Classes

This triple combination belongs to two main antiretroviral drug classes:

1. Abacavir (600mg) – a Nucleoside Reverse Transcriptase Inhibitor (NRTI)

2. Lamivudine (300mg) – another NRTI

3. Dolutegravir (50mg) – an Integrase Strand Transfer Inhibitor (INSTI)

Together, they inhibit multiple stages of the HIV replication cycle, making viral resistance less likely when taken consistently.

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🔬 Mechanism of Action

• Abacavir & Lamivudine: Mimic natural nucleosides and get incorporated into viral DNA during reverse transcription, leading to premature chain termination. This blocks the enzyme reverse transcriptase.

• Dolutegravir: Inhibits the enzyme HIV integrase, preventing integration of viral DNA into the host genome—a crucial step in HIV replication.

The triple blockade of HIV replication significantly lowers viral load and increases CD4+ cell count, which strengthens the immune system.

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📌 Indications

This combination is indicated for:

• Treatment of HIV-1 infection in adults and adolescents aged ≥12 years and weighing ≥40 kg

• Suitable for both treatment-naive and experienced patients, depending on viral resistance profile

It is not a cure but enables people living with HIV to lead healthier, longer lives with effective viral suppression.

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💊 Dosage and Administration

• One tablet once daily, with or without food

• Take at the same time daily to maintain steady drug levels

• Do not skip or split the tablet

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⚠️ Warnings and Precautions

• HLA-B*5701 testing is required before initiating, as Abacavir can cause a life-threatening hypersensitivity reaction in positive individuals

• Monitor for:

  • Liver function, especially in those co-infected with hepatitis B or C

  • Signs of immune reconstitution syndrome

  • Mental health side effects (associated with Dolutegravir)

Avoid alcohol and inform the physician of any history of liver disease or heart conditions.

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🤒 Side Effects

Common:

• Headache

• Nausea

• Fatigue

• Diarrhea

• Insomnia

Serious:

• Hypersensitivity reaction (fever, rash, nausea, shortness of breath)

• Lactic acidosis (rare but serious)

• Liver toxicity

• Mood changes (anxiety, depression)

Discontinue and seek immediate care if symptoms of allergy or liver issues arise.

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🔄 Drug Interactions

• Caution with:

  • Antacids/calcium supplements (can reduce Dolutegravir absorption; separate doses)

  • Rifampin, carbamazepine (may reduce effectiveness)

• Use effective contraception; Dolutegravir may increase the risk of neural tube defects if taken during early pregnancy (consult doctor).

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🧊 Storage Instructions

• Store at room temperature (15–30°C)

• Keep in original packaging, away from moisture and light

• Out of reach of children

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✅ Conclusion

Abacavir + Dolutegravir + Lamivudine offers a powerful, simplified, once-daily regimen for the treatment of HIV. With its triple mechanism of action, it ensures sustained viral suppression, reduced transmission risk, and improved patient outcomes when taken regularly. Proper monitoring and adherence are key to maximizing its long-term benefits.

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Always follow your doctor’s advice, dosage instructions, and never self-medicate.