🦵💊🔥 Indomethacin 25mg Tablet: Powerful Relief for Pain & Inflammation
Indomethacin 25mg is a nonsteroidal anti-inflammatory drug (NSAID) widely used to reduce pain, inflammation, and swelling in various acute and chronic musculoskeletal disorders. As one of the more potent NSAIDs, it is especially effective in treating arthritis-related conditions, gout attacks, and other inflammatory ailments. It works by inhibiting enzymes responsible for producing prostaglandins—chemicals in the body that cause pain and inflammation.
🔬 Mechanism of Action
Indomethacin works by non-selectively inhibiting the cyclooxygenase (COX-1 and COX-2) enzymes, which play a key role in the synthesis of prostaglandins. Prostaglandins are involved in the inflammatory response, pain sensation, and fever. By reducing their production, indomethacin alleviates inflammation, swelling, stiffness, and discomfort.
📌 Indications and Uses
Indomethacin 25mg is used in the treatment of a wide range of painful and inflammatory conditions, including:
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Rheumatoid arthritis
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Osteoarthritis
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Ankylosing spondylitis
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Acute gouty arthritis (gout attacks)
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Bursitis and tendinitis
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Dysmenorrhea (painful menstruation)
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Post-operative pain and inflammation
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Off-label for headache disorders like cluster headaches or PDA closure in infants (in injectable form)
💊 Dosage and Administration
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Standard dose: 25mg 2 to 3 times a day, taken with food or milk to reduce stomach irritation.
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In acute flare-ups (like gout): may be increased or given more frequently under medical supervision.
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Sustained-release formulations are also available for once or twice-daily dosing.
📌 Important: Always follow your doctor’s dosing instructions, and avoid exceeding the recommended daily limit due to potential gastrointestinal and cardiovascular risks.
⚠️ Precautions and Warnings
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Not suitable for long-term use without medical supervision due to risk of ulcers and kidney damage.
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Use caution in patients with:
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History of ulcers or gastrointestinal bleeding
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Heart disease or high blood pressure
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Kidney or liver impairment
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Asthma or allergic disorders
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Avoid during late pregnancy (third trimester) as it may harm the fetus.
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May impair alertness—caution when driving or operating machinery.
🤒 Side Effects
Common:
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Nausea, vomiting
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Headache
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Dizziness
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Stomach pain or discomfort
Serious (seek immediate medical help):
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Gastrointestinal bleeding or ulcers
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High blood pressure
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Kidney or liver dysfunction
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Allergic reactions (rash, swelling, breathing difficulty)
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Mood changes or confusion (rare)
Long-term use requires regular monitoring of blood pressure, kidney function, and liver enzymes.
🔄 Drug Interactions
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Increased risk of bleeding with anticoagulants (e.g., warfarin)
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Reduced effect of antihypertensives
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Additive kidney effects with ACE inhibitors or diuretics
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Avoid with other NSAIDs to reduce cumulative toxicity
🧊 Storage Instructions
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Store at room temperature (15–25°C)
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Keep away from moisture, heat, and direct sunlight
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Keep out of reach of children
📝 Conclusion
Indomethacin 25mg is a powerful NSAID that provides effective relief from pain, inflammation, and swelling associated with a variety of conditions, particularly arthritis and gout. While highly effective, it should be used cautiously and under medical guidance to avoid serious side effects, especially in long-term or high-dose use.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult your healthcare provider for personalized recommendations.
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