Indomethacin 75 mg Capsule
Potent NSAID for Inflammation, Pain, and Arthritis Management
Overview
Indomethacin 75 mg capsule is a non-steroidal anti-inflammatory drug (NSAID) used to treat moderate to severe pain and inflammation. It is commonly prescribed for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout attacks, and certain musculoskeletal injuries. This extended-release formulation provides longer-lasting pain relief with fewer doses.
Ingredient and Mechanism
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Indomethacin (75 mg):
A strong NSAID that inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing the production of prostaglandins—chemical messengers involved in pain, fever, and inflammation. Its potency makes it especially effective for arthritic and inflammatory disorders.
How to Use
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Dosage: Usually 75 mg once or twice daily, depending on the condition.
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Form: Extended-release capsule – swallow whole; do not crush or chew.
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Administration: Take with food or a full glass of water to reduce stomach irritation.
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Duration: Use the lowest effective dose for the shortest possible time.
Common Side Effects
Mild effects that may occur in some patients:
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Gastric discomfort or heartburn
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Headache
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Dizziness or drowsiness
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Nausea or vomiting
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Constipation or diarrhea
Serious Side Effects (Seek urgent medical help)
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Gastrointestinal bleeding or ulceration: black/tarry stools, vomiting blood
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Cardiovascular risk: chest pain, shortness of breath, sudden weakness
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Kidney dysfunction: reduced urine output, swelling in feet or ankles
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Liver damage: jaundice (yellowing of skin/eyes), dark urine
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Severe allergic reaction: rash, itching, facial swelling, difficulty breathing
Monitoring & Follow-Up
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Baseline and Ongoing Tests:
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Liver function tests (LFTs)
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Kidney function (creatinine, urea)
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Blood pressure
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Complete blood count (CBC) for long-term users
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Clinical Review: After 2–4 weeks of use or as symptoms change
Warnings & Precautions
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Gastrointestinal Risk: Use with caution in patients with ulcers or GI bleeding history. Co-prescription with a proton pump inhibitor (PPI) may be considered.
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Cardiovascular Risk: Increased risk of thrombotic events, especially in long-term use.
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Renal Impairment: May worsen kidney function; avoid in patients with severe renal disease.
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Hepatic Disease: Monitor closely in liver-impaired patients.
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Pregnancy: Avoid especially in the third trimester—may harm fetal circulation.
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Elderly: Higher risk of GI, kidney, and heart complications—use with caution.
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Avoid Alcohol: Increases the risk of stomach bleeding.
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Drug Interactions: Caution with anticoagulants, diuretics, lithium, and other NSAIDs.
Summary
Indomethacin 75 mg is a highly effective NSAID used for treating severe inflammatory conditions like arthritis, gout, and musculoskeletal pain. Due to its potency, it provides robust pain relief, but comes with a higher risk of gastrointestinal, cardiovascular, and renal side effects, especially with long-term use. Regular monitoring and appropriate precautions are critical to ensure safe usage. Patients should always follow their healthcare provider’s instructions and never exceed the prescribed dose.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult your healthcare provider for personalized recommendations.
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