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INTAGESIC MR TABLET

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INTAGESIC MR TABLET

Chlorzoxazone 250mg + Diclofenac 50mg + Paracetamol 325mg

Intas Pharmaceuticals Ltd

46 in stock
Description

Description

💡 Overview

This combination tablet is used for relief from musculoskeletal pain, muscle spasms, and inflammation. It provides a synergistic effect, offering both pain relief and muscle relaxation. It is especially useful in conditions like low back pain, sprains, cervical spondylosis, sciatica, and muscle strain.


🧪 Ingredients & Their Function

  1. Chlorzoxazone (250mg) – A centrally acting muscle relaxant that reduces muscle spasms and pain.

  2. Diclofenac Sodium (50mg) – A non-steroidal anti-inflammatory drug (NSAID) that relieves inflammation and pain.

  3. Paracetamol (325mg) – An analgesic and antipyretic used to reduce pain and fever.

Mechanism:

  • Chlorzoxazone depresses reflexes in the spinal cord.

  • Diclofenac inhibits prostaglandin synthesis (COX inhibition), reducing inflammation.

  • Paracetamol elevates the pain threshold in the central nervous system.


✅ Uses

  • Muscular pain and spasms

  • Cervical/lumbar spondylosis

  • Sprains and strains

  • Sports injuries

  • Postoperative musculoskeletal pain

  • Osteoarthritis and rheumatoid arthritis (adjunct)


📋 How to Use

  • Dosage: Usually 1 tablet 2–3 times daily after meals, as prescribed by a physician.

  • Route: Oral, with water.

  • Duration: Short-term use only; prolonged use increases the risk of side effects.

Do not exceed recommended dose.


⚠️ Common Side Effects

  • Drowsiness or dizziness

  • Nausea

  • Heartburn or gastritis

  • Stomach pain

  • Headache

  • Fatigue

These are typically mild and resolve with continued use or dose adjustment.


🚨 Serious Side Effects (Seek Medical Help)

  • Allergic reactions: rash, swelling, difficulty breathing

  • Liver damage: yellowing of skin or eyes, dark urine, fatigue

  • Gastrointestinal bleeding: black/tarry stools, vomiting blood

  • Kidney problems: decreased urination, swelling in legs

  • Severe dizziness or fainting


🔍 Monitoring & Follow-Up

  • Liver Function Tests (LFTs): Especially during prolonged use

  • Kidney Function Tests (KFTs): If used long-term or in elderly

  • GI Monitoring: Watch for signs of ulcers or GI bleeding

  • Mental Alertness: Due to sedative effects of chlorzoxazone


⚠️ Warnings & Precautions

  • Liver Disease: Use with caution — all three components are metabolized by the liver

  • Kidney Impairment: Monitor function during long-term therapy

  • Avoid Alcohol: Increases risk of liver toxicity and GI bleeding

  • Pregnancy & Breastfeeding: Use only if prescribed

  • Driving & Machinery: May cause drowsiness; avoid until you know how it affects you

  • Drug Interactions: Avoid with other NSAIDs, anticoagulants, alcohol, or hepatotoxic drugs


📝 Summary

The Chlorzoxazone 250mg + Diclofenac 50mg + Paracetamol 325mg tablet is an effective triple-action medication for muscle-related pain and inflammation. It combines muscle relaxation with strong anti-inflammatory and pain-relieving effects. While highly effective for short-term use, it must be taken with caution to avoid liver, gastrointestinal, or renal side effects. Always use under medical supervision with appropriate follow-up if used beyond a few days.

Consult your doctor before use and never self-medicate.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.

 

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