ISMO RETARD TABLET

Description

💓 Isosorbide Mononitrate 40mg Tablet: Long-Acting Nitrate for Heart Health

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What is Isosorbide Mononitrate?

Isosorbide Mononitrate (ISMN) is a long-acting nitrate used to prevent angina pectoris (chest pain due to heart disease). It works by relaxing and widening blood vessels, making it easier for blood and oxygen to reach the heart, thereby reducing the heart’s workload.

It is typically used in the chronic management of angina and not for acute attacks.

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🔬 Active Ingredient

• Isosorbide Mononitrate 40mg per tablet

Inactive ingredients vary by manufacturer but may include lactose, starch, magnesium stearate, and cellulose. Extended-release formulations may include special matrix agents.

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💊 How to Use

• Dosage: Typically one 40mg tablet once daily, preferably in the morning.

• Route: Oral, with water.

• Do not crush or chew extended-release tablets.

• Should be taken consistently at the same time each day.

• Not to be used for immediate relief of chest pain.

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✅ Indications

• Prevention of angina pectoris due to coronary artery disease.

• Sometimes used in congestive heart failure as adjunct therapy.

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🤒 Common Side Effects

• Headache (very common, especially when starting)

• Dizziness or lightheadedness

• Flushing (warmth or redness in the face)

• Nausea

• Fatigue

These side effects are usually transient and improve with continued use.

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⚠️ Serious Side Effects

• Severe hypotension (low blood pressure)

• Fainting or syncope

• Fast or irregular heartbeat

• Allergic reactions (rare): rash, itching, or swelling

• Tolerance development (effectiveness may reduce over time)

Seek immediate medical help if fainting or chest pain worsens.

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📈 Monitoring & Follow-Up

• Blood pressure monitoring: especially in the elderly or those on antihypertensives

• Symptom tracking: Document frequency and severity of angina

• Tolerance check: If angina returns despite use, reassess therapy

• Regular follow-up for dose adjustment and effectiveness evaluation

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⚠️ Warnings & Precautions

• Do not use with PDE5 inhibitors (e.g., sildenafil, tadalafil): risk of life-threatening hypotension

• Avoid alcohol: can increase blood pressure-lowering effect

• Use caution in elderly, those with hypotension, or volume depletion

• Not for acute angina attacks

• Gradual dose adjustments needed to avoid withdrawal or rebound angina

• Not recommended during pregnancy or breastfeeding unless clearly needed

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🧾 Summary

Isosorbide Mononitrate 40mg is a prolonged-release nitrate used to prevent angina by relaxing blood vessels and enhancing blood flow to the heart. It is not intended for emergency chest pain relief but for regular, preventive use. While generally effective, it commonly causes headaches and dizziness, particularly early in treatment. Serious risks include severe low blood pressure and drug interactions, especially with erectile dysfunction medications. Monitoring is essential, particularly in patients at risk for hypotension or nitrate tolerance. When taken appropriately, Isosorbide Mononitrate plays a crucial role in improving the quality of life and exercise tolerance in patients with coronary artery disease.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.