JBTOR PLUS LS TABLET

💧💊 Spironolactone 25mg + Torasemide 10mg Tablet: Dual-Action Diuretic for Edema & Heart Failure Management

The Spironolactone 25mg + Torasemide 10mg tablet is a combination diuretic medication used to treat conditions that involve fluid retention (edema) and congestive heart failure (CHF). This fixed-dose formulation combines two different classes of diuretics—Spironolactone, a potassium-sparing diuretic, and Torasemide, a potent loop diuretic—to deliver synergistic action in managing excess fluid while maintaining electrolyte balance.

It is particularly useful in patients who require effective diuresis without the risk of severe potassium loss, a common problem with loop diuretics alone.

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🔬 Mechanism of Action

This combination works by targeting different parts of the nephron in the kidney:

🔹 Torasemide (10mg) – Loop Diuretic

• Acts on the ascending limb of the loop of Henle

• Inhibits sodium, chloride, and water reabsorption

• Results in potent and rapid diuresis

• Helps lower blood pressure and relieve edema

🔹 Spironolactone (25mg) – Aldosterone Antagonist

• Works on the distal convoluted tubule

• Blocks aldosterone, reducing sodium and water retention

• Preserves potassium, preventing hypokalemia

• Offers anti-fibrotic and cardioprotective benefits in heart failure patients

Together, they improve urine output, reduce swelling, and support cardiovascular function.

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📌 Indications and Uses

This combination is commonly prescribed for:

• Congestive Heart Failure (CHF)

• Chronic kidney disease (CKD) with fluid overload

• Cirrhotic edema and ascites

• Hypertension (especially resistant types)

• Nephrotic syndrome

• Patients requiring long-term diuretic therapy with potassium conservation

It is ideal for patients who need strong diuresis but are at risk of low potassium levels.

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💊 Dosage and Administration

• Typical adult dose: One tablet once daily, usually in the morning

• Should be taken with or after food to minimize gastric upset

• Dosage may be adjusted based on:

  • Fluid status

  • Blood pressure

  • Electrolyte levels

  • Kidney function

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⚠️ Precautions and Warnings

• Regular monitoring of:

  • Serum electrolytes (especially potassium and sodium)

  • Renal function

  • Blood pressure

• Avoid in:

  • Hyperkalemia

  • Addison’s disease

  • Severe renal insufficiency

• Caution in elderly, diabetics, and liver-impaired patients

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🤒 Side Effects

Common:

• Frequent urination

• Dizziness or low blood pressure

• Muscle cramps

• Fatigue

• Nausea

Less Common/Serious:

• Hyperkalemia (especially from Spironolactone)

• Gynecomastia or breast tenderness

• Electrolyte imbalance (if not monitored)

• Kidney dysfunction

Seek medical help if you experience irregular heartbeat, confusion, or muscle weakness.

---

🔄 Drug Interactions

• Avoid with:

  • ACE inhibitors, ARBs, or potassium supplements – risk of hyperkalemia

  • NSAIDs – may reduce diuretic effect

• May enhance effects of other antihypertensives

---

🧊 Storage Instructions

• Store below 25°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

---

📝 Conclusion

Spironolactone 25mg + Torasemide 10mg is a well-balanced diuretic combination that offers strong fluid removal with potassium conservation. It is particularly suited for heart failure, kidney disease, and cirrhosis-related edema, where fluid overload and electrolyte management are critical. When used under proper medical supervision, it offers effective symptom relief and long-term cardiovascular support.

💧🫀💊 Spironolactone 25mg + Torasemide 10mg Tablet: Dual-Action Diuretic for Edema & Heart Failure Management

The Spironolactone 25mg + Torasemide 10mg tablet is a combination diuretic medication used to treat conditions that involve fluid retention (edema) and congestive heart failure (CHF). This fixed-dose formulation combines two different classes of diuretics—Spironolactone, a potassium-sparing diuretic, and Torasemide, a potent loop diuretic—to deliver synergistic action in managing excess fluid while maintaining electrolyte balance.

It is particularly useful in patients who require effective diuresis without the risk of severe potassium loss, a common problem with loop diuretics alone.

---

🔬 Mechanism of Action

This combination works by targeting different parts of the nephron in the kidney:

🔹 Torasemide (10mg) – Loop Diuretic

• Acts on the ascending limb of the loop of Henle

• Inhibits sodium, chloride, and water reabsorption

• Results in potent and rapid diuresis

• Helps lower blood pressure and relieve edema

🔹 Spironolactone (25mg) – Aldosterone Antagonist

• Works on the distal convoluted tubule

• Blocks aldosterone, reducing sodium and water retention

• Preserves potassium, preventing hypokalemia

• Offers anti-fibrotic and cardioprotective benefits in heart failure patients

Together, they improve urine output, reduce swelling, and support cardiovascular function.

---

📌 Indications and Uses

This combination is commonly prescribed for:

• Congestive Heart Failure (CHF)

• Chronic kidney disease (CKD) with fluid overload

• Cirrhotic edema and ascites

• Hypertension (especially resistant types)

• Nephrotic syndrome

• Patients requiring long-term diuretic therapy with potassium conservation

It is ideal for patients who need strong diuresis but are at risk of low potassium levels.

---

💊 Dosage and Administration

• Typical adult dose: One tablet once daily, usually in the morning

• Should be taken with or after food to minimize gastric upset

• Dosage may be adjusted based on:

  • Fluid status

  • Blood pressure

  • Electrolyte levels

  • Kidney function

---

⚠️ Precautions and Warnings

• Regular monitoring of:

  • Serum electrolytes (especially potassium and sodium)

  • Renal function

  • Blood pressure

• Avoid in:

  • Hyperkalemia

  • Addison’s disease

  • Severe renal insufficiency

• Caution in elderly, diabetics, and liver-impaired patients

---

🤒 Side Effects

Common:

• Frequent urination

• Dizziness or low blood pressure

• Muscle cramps

• Fatigue

• Nausea

Less Common/Serious:

• Hyperkalemia (especially from Spironolactone)

• Gynecomastia or breast tenderness

• Electrolyte imbalance (if not monitored)

• Kidney dysfunction

Seek medical help if you experience irregular heartbeat, confusion, or muscle weakness.

---

🔄 Drug Interactions

• Avoid with:

  • ACE inhibitors, ARBs, or potassium supplements – risk of hyperkalemia

  • NSAIDs – may reduce diuretic effect

• May enhance effects of other antihypertensives

---

🧊 Storage Instructions

• Store below 25°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

---

📝 Conclusion

Spironolactone 25mg + Torasemide 10mg is a well-balanced diuretic combination that offers strong fluid removal with potassium conservation. It is particularly suited for heart failure, kidney disease, and cirrhosis-related edema, where fluid overload and electrolyte management are critical. When used under proper medical supervision, it offers effective symptom relief and long-term cardiovascular support.