LENOME 10 CAPSULE

🧬💊⚠️ Lenalidomide 10mg Tablet: A Targeted Therapy for Blood Cancers & Beyond

Lenalidomide 10mg is an immunomodulatory and anti-neoplastic agent, primarily used in the treatment of certain blood cancers and bone marrow disorders. It is structurally related to thalidomide but has enhanced potency and a more favorable safety profile. Lenalidomide works by modifying the immune system, suppressing tumor growth, and inhibiting abnormal cell proliferation, making it a valuable medication in modern hematologic oncology.

It is prescription-only, typically used under the supervision of an oncologist or hematologist.

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🔬 Mechanism of Action

Lenalidomide has a multi-faceted mechanism:

• Immunomodulation: Enhances T-cell and natural killer (NK) cell activity to attack cancer cells.

• Anti-angiogenic effect: Inhibits new blood vessel formation in tumors, starving them of nutrients.

• Direct cytotoxic action: Kills malignant cells in multiple myeloma and myelodysplastic syndromes (MDS).

• Alters cytokine production, reducing inflammation and disease progression.

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📌 Indications and Uses

Lenalidomide 10mg is used in:

🧪 Blood Cancers

• Multiple Myeloma (MM): In combination with dexamethasone or other agents for newly diagnosed and relapsed cases.

• Myelodysplastic Syndromes (MDS): Especially those with deletion 5q cytogenetic abnormality.

• Mantle Cell Lymphoma (MCL): For patients who have received at least one prior therapy.

• Chronic Lymphocytic Leukemia (CLL): In clinical trials and select treatment protocols.

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💊 Dosage and Administration

• Dose varies by indication, commonly 10–25mg once daily.

• For MDS, typically 10mg once daily until disease progression or unacceptable toxicity.

• Administered in 28-day cycles (21 days on, 7 days off).

• Take with or without food, preferably at the same time each day.

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⚠️ Precautions and Warnings

• Pregnancy Risk: Category X – Strictly contraindicated in pregnancy due to severe birth defects.

• Requires enrollment in REMS (Risk Evaluation and Mitigation Strategy) program.

• Males and females of childbearing potential must use effective contraception.

Use cautiously in patients with:

• Renal impairment (dose adjustment needed)

• Thromboembolic risk (may require blood thinners)

• Infection risk (due to immunosuppression)

Regular monitoring of blood counts is mandatory.

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🤒 Common Side Effects

• Fatigue

• Diarrhea or constipation

• Low white blood cell (neutropenia) or platelet count (thrombocytopenia)

• Skin rash or itching

• Increased risk of blood clots (deep vein thrombosis, pulmonary embolism)

Serious side effects:

• Severe bone marrow suppression

• Liver function changes

• Secondary malignancies (rare)

• Hypothyroidism

Discontinue immediately in case of allergic reaction or severe toxicity.

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🔄 Drug Interactions

• Risk of blood clots increases when used with dexamethasone, erythropoietin, or hormone therapy

• May interact with anticoagulants – monitor INR closely if on warfarin

• Use caution with live vaccines due to immunosuppression

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🧊 Storage and Handling

• Store at 20–25°C, away from moisture and light

• Do not crush or open capsules

• Handle with gloves if you are not the patient

• Keep out of reach of children and pregnant women

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📝 Conclusion

Lenalidomide 10mg is a life-extending medication for patients with multiple myeloma, MDS, and lymphomas, working through immune modulation and direct anti-cancer activity. Its powerful benefits come with serious safety responsibilities, especially regarding pregnancy and bone marrow suppression. When used carefully, it plays a crucial role in modern hematologic cancer therapy, often improving survival and quality of life.

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Always follow your doctor’s advice, dosage instructions, and never self-medicate.