LEVERA XR 500 TABLET

🧠⚡💊 Levetiracetam 500mg Tablet: Modern Antiepileptic for Seizure Control and Brain Stability

Levetiracetam 500mg is a widely used antiepileptic (anticonvulsant) medication, prescribed for the treatment of various types of seizure disorders, including partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures. Known for its rapid onset, minimal drug interactions, and good tolerability, Levetiracetam is suitable for both monotherapy and adjunctive therapy in adults and children with epilepsy.

It is commonly marketed under brand names like Keppra and is valued for its ability to stabilize brain electrical activity without heavily sedating the patient.

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🔬 Mechanism of Action

Levetiracetam’s precise mechanism is not fully understood, but it is believed to act via:

• Binding to SV2A (synaptic vesicle protein 2A) in the brain

• Modulating neurotransmitter release

• Inhibiting synchronized neuronal firing associated with seizure activity

• Reducing neuronal excitability

Unlike older anticonvulsants, it does not affect GABA or glutamate receptors directly, resulting in fewer CNS side effects and interactions.

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📌 Indications and Uses

Levetiracetam 500mg tablets are indicated for:

• Partial-onset seizures (with or without secondary generalization)

• Myoclonic seizures in juvenile myoclonic epilepsy

• Primary generalized tonic-clonic seizures

• May be used in:

  • Post-stroke seizure prevention (off-label)

  • Brain injury-related seizures

  • Patients with poor response to older antiepileptics

It is often used in combination with other antiepileptic drugs or as monotherapy in adults.

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💊 Dosage and Administration

• Initial dose: Typically 500mg twice daily

• May be increased gradually (by 500mg every 2 weeks) up to a maximum of 3000mg/day depending on response and tolerability

• Tablets should be swallowed whole with or without food

• Dosage adjustments are needed in renal impairment

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⚠️ Precautions and Warnings

• Suicidal thoughts or behavior may occur; monitor mental health closely

• Use with caution in patients with:

  • Depression, anxiety, or psychiatric illness

  • Severe kidney disease

• Not a cure for epilepsy, but controls seizures with regular use

• Abrupt discontinuation may cause rebound seizures—taper gradually under doctor’s supervision

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🤒 Side Effects

Common:

• Drowsiness or fatigue

• Dizziness

• Headache

• Irritability or behavioral changes (especially in children)

• Nasopharyngitis

Less common but serious:

• Mood swings, depression, hallucinations, aggression

• Coordination problems

• Rare allergic reactions (rash, swelling)

Inform your doctor immediately if any changes in mood or behavior occur.

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🔄 Drug Interactions

• Minimal interaction with other medications

• Does not affect liver enzymes, unlike many older antiepileptics

• Safe for use with oral contraceptives, anticoagulants, and other CNS drugs

This makes Levetiracetam ideal for patients on multiple medications.

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🧊 Storage Instructions

• Store at 15–30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

Levetiracetam 500mg tablet is a safe, modern, and effective antiepileptic used to control a wide range of seizures. With its unique mechanism, low interaction potential, and favorable side effect profile, it is especially valuable for long-term epilepsy management in both adults and children. Regular use and medical monitoring ensure optimal seizure control and improved quality of life.