LOBATE GM NEO CREAM

🧴🦠🧬 Clobetasol 0.05% + Miconazole 2% + Neomycin 0.5% Cream: Triple-Action Relief for Skin Infections & Inflammation

This combination topical formulation blends three powerful ingredients—Clobetasol Propionate 0.05%, Miconazole Nitrate 2%, and Neomycin Sulfate 0.5%—to provide broad-spectrum treatment for a variety of inflammatory skin conditions complicated by fungal and bacterial infections. It delivers anti-inflammatory, antifungal, and antibacterial effects in one cream, offering rapid and comprehensive relief.

---

🔬 Composition and Mechanism of Action

🔹 Clobetasol Propionate (0.05%) – Super-potent corticosteroid

• Reduces inflammation, redness, swelling, and itching

• Acts by suppressing the release of inflammatory chemicals (cytokines)

• Provides fast symptom relief in eczema, dermatitis, and allergic reactions

🔹 Miconazole Nitrate (2%) – Broad-spectrum antifungal

• Disrupts fungal cell membrane by inhibiting ergosterol synthesis

• Kills or inhibits growth of fungi responsible for ringworm, candidiasis, tinea infections

• Also effective against some Gram-positive bacteria

🔹 Neomycin Sulfate (0.5%) – Aminoglycoside antibiotic

• Inhibits protein synthesis in bacteria by binding to 30S ribosomal subunits

• Effective against Gram-negative and some Gram-positive bacteria

• Helps prevent secondary bacterial infections in broken or inflamed skin

Together, these agents provide targeted relief from mixed microbial infections with associated inflammation and itching.

---

📌 Indications and Uses

This triple-combination cream is indicated for:

• Fungal skin infections (e.g., tinea corporis, tinea cruris, tinea pedis)

• Intertrigo and candidal dermatitis

• Eczematous dermatitis with secondary infection

• Seborrheic dermatitis

• Allergic and contact dermatitis with microbial contamination

• Infected psoriasis or lichen simplex chronicus

It’s especially useful when inflammation is severe or when fungal infections are complicated by bacterial superinfection.

---

💡 How to Use

• Apply a thin layer to the affected area twice daily (or as prescribed)

• Gently rub in and wash hands after use

• Avoid application on face, groin, or underarms unless advised by a doctor

• Do not cover with airtight dressings unless directed

Treatment duration is usually limited to 1–2 weeks to avoid steroid side effects.

---

⚠️ Precautions and Warnings

• For external use only

• Avoid contact with eyes, nose, and mouth

• Not suitable for long-term use, especially on large surface areas

• Use with caution in:

  • Children

  • Pregnant or breastfeeding women

  • Patients with skin thinning or rosacea

Prolonged use may lead to skin thinning, acne, stretch marks, or delayed wound healing.

---

🤒 Side Effects

Common:

• Skin irritation, burning, or dryness

• Itching or redness at application site

Serious/Rare:

• Skin atrophy (thinning)

• Hypopigmentation

• Cushingoid symptoms (if overused)

• Allergic reaction to neomycin (contact dermatitis)

Discontinue use if any severe rash or irritation occurs.

---

🔄 Drug Interactions

• Avoid using with other topical steroids or antifungals unless prescribed

• Neomycin may cause allergic sensitivity in some patients

---

🧊 Storage Instructions

• Store below 25°C in a cool, dry place

• Keep the tube tightly closed

• Keep out of reach of children

---

📝 Conclusion

The Clobetasol 0.05% + Miconazole 2% + Neomycin 0.5% cream is a powerful and effective topical solution for treating mixed skin infections involving inflammation, fungi, and bacteria. It offers quick relief from itching and redness, while addressing the underlying microbial causes, making it ideal for short-term use under medical supervision.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.