Description
💊 Levofloxacin 750mg Tablet – Powerful Antibiotic for Serious Infections
🦠 What is Levofloxacin 750mg?
Levofloxacin 750mg is a broad-spectrum fluoroquinolone antibiotic used to treat moderate to severe bacterial infections. It works by inhibiting DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication and repair, ultimately killing the bacteria.
The 750mg dosage is typically reserved for more aggressive or deep-seated infections, requiring higher blood concentrations for faster and stronger effects.
✅ Indications / Uses
Levofloxacin 750mg is commonly prescribed for:
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Severe community-acquired pneumonia
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Complicated urinary tract infections (cUTIs)
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Acute pyelonephritis (kidney infection)
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Chronic bacterial prostatitis
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Skin and soft tissue infections
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Inhalational anthrax (post-exposure)
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Plague (Yersinia pestis)
This higher-strength tablet is not typically first-line for milder infections due to increased risk of side effects.
🔬 Composition / Ingredients
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Active Ingredient: Levofloxacin hemihydrate (equivalent to 750 mg levofloxacin base)
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Inactive Ingredients: May include microcrystalline cellulose, hypromellose, crospovidone, magnesium stearate, titanium dioxide, polyethylene glycol, and coloring agents (varies by manufacturer)
⚠️ Precautions and Warnings
Levofloxacin 750mg is a potent drug and should be used with caution. Major precautions include:
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Tendinitis and Tendon Rupture: Especially in the elderly or those on corticosteroids.
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Peripheral Neuropathy: May be irreversible; early signs include numbness or tingling.
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Central Nervous System Effects: Headache, insomnia, seizures, and hallucinations may occur.
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QT Prolongation: Can cause dangerous heart rhythm disturbances.
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Hypoglycemia or Hyperglycemia: Especially in diabetics on insulin or oral antidiabetics.
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Photosensitivity: Avoid sun/UV light during treatment.
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Pregnancy/Breastfeeding: Use only if benefits outweigh risks; not recommended for children due to cartilage concerns.
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Renal Impairment: Dose adjustment required.
💥 Side Effects
Common:
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Nausea
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Diarrhea
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Headache
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Dizziness
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Insomnia
Less Common but Serious:
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Tendon rupture
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Seizures
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Hepatotoxicity (liver issues)
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Allergic reactions (anaphylaxis)
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Clostridioides difficile-associated diarrhea
Seek immediate medical attention for swelling/pain in joints, yellowing of eyes/skin, or allergic symptoms.
📋 Dosage and Administration
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Standard Dose: One 750mg tablet once daily
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Duration: Usually 5–7 days depending on the condition
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Take with or without food; do not crush or chew
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Stay hydrated and avoid excessive caffeine/alcohol
Avoid taking with antacids, calcium, iron, or zinc supplements within 2 hours of dosing, as they reduce absorption.
⚖️ Drug Interactions
Levofloxacin may interact with:
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Warfarin (↑ bleeding risk)
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NSAIDs (↑ seizure risk)
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Antiarrhythmics (↑ QT prolongation)
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Diabetes medications (blood sugar fluctuations)
Always consult your doctor about current medications.
📌 Conclusion
Levofloxacin 750mg is a high-dose antibiotic reserved for serious infections that demand strong and rapid antibacterial action. While highly effective, it comes with significant risks, making medical supervision essential. Complete the full course even if you feel better to prevent resistance.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
