LUPRODEX DEPOT 11.25

🧬💉⚖️ Leuprolide 11.25mg Injection: Hormonal Control for Serious Conditions

Leuprolide 11.25mg is a long-acting gonadotropin-releasing hormone (GnRH) agonist, commonly used in the treatment of hormone-sensitive conditions such as prostate cancer, endometriosis, uterine fibroids, and central precocious puberty (CPP). It works by temporarily suppressing the body’s production of sex hormones — testosterone in males and estrogen in females — thereby controlling disease progression and reducing symptoms.

This formulation is administered via intramuscular (IM) or subcutaneous (SC) injection and is typically given once every 3 months, offering the advantage of long-term control with fewer injections.

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🔬 Mechanism of Action

Leuprolide is a GnRH agonist that initially stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). However, with continuous administration, it desensitizes GnRH receptors, leading to suppressed LH and FSH production. This results in:

• ⬇️ Testosterone in males (medical castration)

• ⬇️ Estrogen in females (menopausal-like effect)

This hormonal suppression helps control hormone-dependent conditions.

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📌 Indications and Uses

🔹 In Men:

• Advanced or metastatic prostate cancer
  Slows tumor growth and relieves cancer symptoms by reducing testosterone levels.

🔹 In Women:

• Endometriosis
  Reduces pain, inflammation, and lesion size by suppressing estrogen.

• Uterine fibroids (preoperative use)
  Shrinks fibroid size and improves anemia before surgery.

🔹 In Children:

• Central precocious puberty (CPP)
  Halts early puberty development by regulating hormone production.

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💊 Dosage and Administration

• Formulation: 11.25mg depot injection

• Route: Intramuscular or subcutaneous

• Frequency: Every 12 weeks (3 months)

Administer under medical supervision. The injection site should be rotated to prevent irritation.

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⚠️ Precautions and Warnings

• Initial hormone surge (flare-up) may temporarily worsen symptoms during the first 1–2 weeks

• Bone density loss with long-term use—especially in women

• Use with caution in:

  • Patients with cardiovascular disease

  • Osteoporosis

  • Diabetes

• Not recommended during pregnancy or breastfeeding

Monitor hormone levels, symptoms, and bone health during treatment.

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🤒 Side Effects

Common:

• Hot flashes

• Sweating

• Decreased libido

• Fatigue

• Mood changes

• Injection site pain

Serious:

• Bone thinning/osteoporosis

• Heart rhythm changes

• Depression or emotional changes

• Initial flare-up of symptoms (e.g., bone pain in prostate cancer)

In children, monitor growth and pubertal suppression effectiveness.

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🔄 Drug Interactions

• Use caution with drugs affecting QT interval (e.g., antiarrhythmics)

• Avoid use with hormonal therapies unless directed

• No major metabolic drug interactions reported

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🧊 Storage Instructions

• Store in refrigerator (2°C–8°C)

• Protect from light and do not freeze

• Use immediately once reconstituted

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📝 Conclusion

Leuprolide 11.25mg is a vital therapy for managing complex hormone-dependent disorders. Its quarterly dosing improves patient compliance while effectively reducing estrogen or testosterone levels. Though powerful, it must be used under close medical supervision due to its profound impact on hormonal balance and associated risks. Proper monitoring can lead to significant symptom control, slowed disease progression, and improved quality of life for patients facing serious conditions like prostate cancer, endometriosis, or CPP.

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Always follow your doctor’s advice, dosage instructions, and never self-medicate.