LUPRORIN DEPOT 3.75

🧬💉⚖️ Leuprolide 3.75mg Injection: Hormonal Control for Cancer and Endometriosis

Leuprolide 3.75mg is a gonadotropin-releasing hormone (GnRH) agonist, widely used as a hormonal therapy for hormone-sensitive conditions such as prostate cancer, endometriosis, uterine fibroids, and central precocious puberty (CPP). Administered via injection, Leuprolide acts by suppressing sex hormone production (testosterone in males and estrogen in females), thereby reducing the progression of hormone-driven diseases.

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🔬 Mechanism of Action

Leuprolide initially stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), causing a temporary rise in sex hormones (known as the “flare effect”). Continued administration desensitizes GnRH receptors in the pituitary gland, leading to decreased LH and FSH secretion, which results in:

• Reduced testosterone in men

• Lower estrogen in women

This reversible medical castration helps slow the growth of hormone-dependent tumors and tissues.

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📌 Indications and Uses

Leuprolide 3.75mg is prescribed for:

🧔 Prostate Cancer

• Used in advanced or metastatic prostate cancer

• Helps reduce tumor growth and relieve symptoms by suppressing testosterone

👩 Endometriosis

• Reduces pelvic pain and lesion growth by suppressing estrogen

• Often used for 6 months (may be extended with add-back therapy)

👩‍⚕️ Uterine Fibroids

• Shrinks fibroids before surgery

• Controls heavy menstrual bleeding

👧 Central Precocious Puberty (CPP)

• Delays early onset puberty in children by inhibiting premature sex hormone release

🔄 Assisted Reproductive Technology (ART)

• Controls ovulation timing in fertility treatment protocols

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💉 Dosage and Administration

• Leuprolide 3.75mg is typically given as a monthly intramuscular injection

• Administered by a healthcare provider

• Treatment duration depends on the condition:

  • Prostate cancer: long-term use

  • Endometriosis/Fibroids: usually up to 6 months

  • CPP: until appropriate pubertal age

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⚠️ Precautions and Warnings

• Initial hormone flare: May worsen symptoms temporarily (e.g., bone pain in prostate cancer)

• Monitor bone density in long-term use (risk of osteoporosis)

• Caution in patients with:

  • Cardiovascular disease

  • Depression

  • Diabetes

• Not recommended in pregnancy or breastfeeding

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🤒 Side Effects

Common:

• Hot flashes

• Sweating

• Decreased libido

• Mood swings

• Vaginal dryness or testicular shrinkage

• Headache or injection site pain

Serious/Rare:

• Bone thinning (osteopenia/osteoporosis)

• Severe depression

• Elevated blood sugar or cholesterol

• Cardiovascular risks (especially in men)

Report any severe mood changes, bone pain, or unusual bleeding.

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🔄 Drug Interactions

• May interact with antidiabetic medications, altering glucose control

• Hormone-based therapies may reduce its effectiveness

• Combine with “add-back therapy” (low-dose estrogen/progestin) to reduce side effects in long-term use for endometriosis

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🧊 Storage Instructions

• Store vials at 2–25°C (room temperature)

• Protect from light and do not freeze

• Use under medical supervision

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📝 Conclusion

Leuprolide 3.75mg injection is a powerful hormonal regulator, offering effective treatment for conditions driven by excess testosterone or estrogen. Though side effects like hot flashes and bone loss are possible, its benefits in cancer management, pain control, and puberty regulation make it an essential tool in modern endocrine and oncologic care. Regular monitoring and medical supervision ensure safe and effective therapy.

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Always follow your doctor’s advice, dosage instructions, and never self-medicate.