MIZOCAM DT 20 TABLET

🦴🔥💊 Piroxicam 20mg Tablet: Long-Acting NSAID for Pain, Inflammation & Joint Disorders

Piroxicam 20mg is a nonsteroidal anti-inflammatory drug (NSAID) used for the relief of pain, inflammation, and stiffness associated with various musculoskeletal and joint disorders. As a long-acting NSAID, it is commonly prescribed for arthritis, back pain, muscle strains, and postoperative discomfort. Its once-daily dosing makes it convenient for chronic conditions like osteoarthritis and rheumatoid arthritis, offering sustained symptom control.

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🔬 Mechanism of Action

Piroxicam works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), which are responsible for the synthesis of prostaglandins—chemical mediators involved in pain, inflammation, and fever.

Key effects include:

• Reduction of inflammation

• Pain relief

• Lowering of joint swelling and stiffness

• Fever reduction (less common use)

Unlike short-acting NSAIDs, Piroxicam has a long half-life (about 50 hours), allowing for once-daily administration.

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📌 Indications and Uses

Piroxicam 20mg is used in the management of:

• Osteoarthritis – reduces joint pain and improves mobility

• Rheumatoid arthritis – alleviates chronic joint inflammation and swelling

• Ankylosing spondylitis – relieves spinal stiffness and discomfort

• Musculoskeletal pain – including sprains, strains, and back pain

• Postoperative or dental pain

• Gout (acute attacks) – off-label use

It is especially beneficial in chronic inflammatory conditions requiring long-term pain management.

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💊 Dosage and Administration

• Typical adult dose: 20mg once daily

• In some cases, 10mg twice daily may be used to minimize gastrointestinal side effects

• Should be taken with food or milk to reduce gastric irritation

• Duration of use should be as short as possible based on clinical need

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⚠️ Precautions and Warnings

• Not recommended for long-term use without monitoring due to gastrointestinal, renal, and cardiovascular risks

• Contraindicated in:

  • Peptic ulcer disease

  • Gastrointestinal bleeding

  • Severe heart, liver, or kidney impairment

  • Asthma triggered by NSAIDs

• Use with caution in:

  • Elderly patients

  • Those with a history of hypertension or heart disease

• Avoid combining with other NSAIDs or blood thinners unless advised

Routine monitoring may include:

• Kidney function tests

• Liver function

• Blood pressure

• Complete blood count for signs of bleeding or anemia

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🤒 Side Effects

Common:

• Nausea, vomiting

• Stomach pain or indigestion

• Headache or dizziness

• Diarrhea or constipation

Serious:

• Gastrointestinal bleeding or ulceration

• Kidney dysfunction

• Hypertension or fluid retention

• Allergic reactions (rash, itching, anaphylaxis)

Seek urgent care for symptoms like black stools, vomiting blood, severe abdominal pain, or difficulty breathing.

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🔄 Drug Interactions

• Increased risk of bleeding with:

  • Aspirin

  • Warfarin or other anticoagulants

• May reduce the effectiveness of:

  • Antihypertensives (ACE inhibitors, diuretics)

• Use cautiously with methotrexate, lithium, or corticosteroids

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🧊 Storage Instructions

• Store below 25°C, in a dry place

• Keep away from heat, light, and moisture

• Keep out of reach of children

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📝 Conclusion

Piroxicam 20mg tablet is a potent, long-acting NSAID ideal for managing chronic inflammatory conditions like arthritis. Its once-daily dosing offers convenience and consistent relief, but it must be used with caution due to potential gastrointestinal and cardiovascular side effects. Under proper medical guidance, it provides effective, long-lasting pain control and improves quality of life in patients with joint and musculoskeletal disorders.