Description
💓 Nitroglycerin 6.4mg Extended-Release Tablet
Advanced Vasodilator Therapy for Angina & Cardiovascular Support
Introduction:
Nitroglycerin 6.4mg is a long-acting nitrate formulation used in the prevention and management of chronic stable angina pectoris—chest pain resulting from reduced oxygen supply to the heart muscle. Unlike sublingual nitroglycerin used for acute relief, this extended-release tablet is designed for ongoing prevention, maintaining consistent blood levels over time and reducing the frequency of angina episodes.
This dosage is typically used in patients with moderate to severe angina who require sustained nitrate therapy to manage daily symptoms and improve exercise tolerance.
Mechanism of Action:
Nitroglycerin is converted to nitric oxide (NO) in the body, which activates guanylate cyclase, leading to increased levels of cyclic GMP. This causes smooth muscle relaxation, resulting in the dilation of veins (reducing preload) and arteries (reducing afterload). The net effect is decreased cardiac workload and improved oxygen delivery to the heart muscle, alleviating angina.
Therapeutic Uses:
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Chronic stable angina pectoris
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Angina prophylaxis in coronary artery disease
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As adjunctive therapy in heart failure and post-myocardial infarction in select patients
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Management of coronary vasospasm
Dosage and Administration:
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Typically taken once or twice daily, depending on clinical need and prescriber instructions
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Should be taken with water, do not chew or crush the tablet
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A nitrate-free interval (typically overnight) is recommended to avoid the development of tolerance
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Do not use for immediate angina relief; not a substitute for sublingual nitroglycerin
Key Benefits:
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Extended-release formulation offers long-term angina prevention
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Reduces the frequency and severity of chest pain episodes
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Improves exercise tolerance and quality of life in patients with chronic angina
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Supports cardiac efficiency by lowering myocardial oxygen demand
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Enhances adherence through simplified dosing schedules
Common Side Effects:
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Headache (very common during initial use; may lessen over time)
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Dizziness or orthostatic hypotension
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Flushing or warmth of the face and neck
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Palpitations or mild increase in heart rate
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Nausea or mild gastrointestinal discomfort
Serious (Rare) Adverse Effects:
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Severe hypotension or syncope
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Reflex tachycardia
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Allergic skin reactions
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Worsening of angina if tolerance develops
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Methemoglobinemia (very rare)
Precautions:
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Do not use with PDE-5 inhibitors (e.g., sildenafil, tadalafil) due to risk of profound hypotension
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Caution in patients with hypotension, anemia, or head trauma
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Use with care in those with severe hepatic or renal impairment
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Tolerance can develop with continuous use—maintain nitrate-free intervals
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Regular monitoring of blood pressure and symptom control is recommended
Storage:
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Store at room temperature (15–30°C) in a dry place
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Protect from moisture and direct sunlight
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Keep out of reach of children
Conclusion:
Nitroglycerin 6.4mg extended-release tablet is a powerful tool in the long-term management of chronic angina. It helps prevent daily chest pain episodes, supports heart function, and improves quality of life for patients with coronary artery disease. When used as prescribed, it ensures consistent nitrate therapy with reduced risk of tolerance and maximum cardiovascular benefit.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
