MYORIL 8 CAPSULE

💪🔥💊 Thiocolchicoside 8mg Capsule: High-Potency Muscle Relaxant for Painful Spasms & Stiffness

Thiocolchicoside 8mg capsule is a powerful centrally acting muscle relaxant with anti-inflammatory and mild analgesic effects, used for treating acute muscle spasms, painful musculoskeletal conditions, and neurological stiffness. It is a semisynthetic derivative of colchicoside (from Colchicum autumnale) and is known for offering effective relief from muscle rigidity, cramps, and nerve-related pain without causing excessive sedation. This higher strength formulation (8mg) is suitable for adults with moderate to severe muscle spasm-related conditions.

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🔬 Mechanism of Action

Thiocolchicoside works on the central nervous system (CNS) by binding selectively to GABA-A and glycine receptors, which are involved in inhibitory neurotransmission. Its core actions include:

• Inhibiting abnormal muscle contraction at the spinal cord and brain level

• Relaxing skeletal muscles involved in pain and stiffness

• Reducing nerve root irritation

• Providing mild anti-inflammatory benefits

It preserves cognitive function and coordination better than many traditional muscle relaxants, making it more tolerable during daily activities.

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📌 Indications and Uses

Thiocolchicoside 8mg capsule is prescribed in the short-term treatment of:

• Acute muscular spasms of the back, neck, or limbs

• Low back pain (lumbago)

• Cervical and lumbar spondylitis/spondylosis

• Sciatica or nerve root compression syndromes

• Post-surgical muscle stiffness or trauma-induced contractures

• Torticollis (wry neck)

• Muscle rigidity in certain neurological conditions (off-label)

Often used in combination with non-steroidal anti-inflammatory drugs (NSAIDs) for faster relief.

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💊 Dosage and Administration

• Recommended adult dose: One 8mg capsule twice daily, typically after meals

• Duration: Should not exceed 7 consecutive days for oral administration

• Not suitable for children or adolescents under 16 years

The capsule should be swallowed whole with water, not crushed or chewed.

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⚠️ Precautions and Warnings

• Contraindicated in:

  • Pregnant and breastfeeding women (can cause embryo-fetal toxicity)

  • Women of childbearing potential not using contraception

  • Patients with a history of epilepsy or seizures

• Use with caution in:

  • Patients with kidney or liver disorders

  • Elderly patients

• Not recommended for long-term therapy due to potential genotoxic and fertility risks (seen in animal studies)

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🤒 Side Effects

Common side effects:

• Drowsiness (mild)

• Nausea or abdominal discomfort

• Diarrhea

• Skin rash or itching

Rare but serious:

• Seizures (especially in predisposed individuals)

• Liver dysfunction

• Allergic reactions

• Reproductive toxicity with prolonged, high-dose usage (in experimental settings)

Seek immediate care if experiencing convulsions, jaundice, or severe rash.

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🔄 Drug Interactions

• May potentiate sedative effects of CNS depressants (e.g., alcohol, sleeping pills)

• Should be avoided or carefully used in patients on antiepileptic drugs

• Often prescribed in combination with Diclofenac, Aceclofenac, or Paracetamol

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🧊 Storage Instructions

• Store at 15–25°C in a dry place, away from sunlight

• Keep out of reach of children

• Do not use expired medication

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📝 Conclusion

Thiocolchicoside 8mg capsule is a highly effective muscle relaxant designed for short-term relief of moderate to severe muscle spasms, back and neck pain, and post-traumatic muscle stiffness. Its ability to relax muscles without causing heavy sedation makes it ideal for patients who want quick recovery with functional independence. Short-duration use under medical supervision ensures safe and powerful relief from muscular discomfort.