MYOTOP 450 TABLET

🦴💪🛑 Tolperisone 450mg Tablet: A Muscle Relaxant for Spasticity and Pain Relief

Tolperisone 450mg is a centrally acting muscle relaxant used primarily for the treatment of muscle spasticity, muscle pain, and neurological conditions involving abnormal muscle tone. It is commonly prescribed in orthopedic, neurologic, and rehabilitation settings to relieve involuntary muscle contractions and associated discomfort. Its unique combination of muscle relaxation without sedation makes it a valuable option for maintaining patient alertness and mobility during therapy.

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🔬 Mechanism of Action

Tolperisone works by acting on the central nervous system, specifically at the level of the brainstem and spinal cord, to inhibit reflex pathways involved in muscle contraction.

• It stabilizes nerve membranes and inhibits sodium and calcium ion channels, leading to decreased neuronal excitability.

• It suppresses excessive skeletal muscle activity by blocking polysynaptic reflexes.

• It improves blood flow to muscles by having vasodilatory effects.

• It has minimal sedative action, allowing patients to continue their daily activities without drowsiness.

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📌 Indications and Uses

Tolperisone 450mg is indicated in adults for the treatment of:

• Muscle spasms and spasticity due to:

  • Neurological disorders like multiple sclerosis, stroke, cerebral palsy, spinal cord injuries

  • Musculoskeletal conditions such as spondylosis, cervical/lumbar spondylitis, sciatica

  • Post-operative muscle pain or trauma-related muscular stiffness

• Painful muscular conditions including back pain, neck stiffness, and frozen shoulder

Often used in combination with NSAIDs or physiotherapy for enhanced effectiveness.

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💊 Dosage and Administration

• Standard adult dose: 450mg per day, usually divided into three doses of 150mg each

• Tolperisone 450mg may also be prescribed as one single dose depending on formulation and patient response

• Take after food to reduce gastric discomfort

• Swallow tablet whole with water; do not crush or chew

The exact dose may vary based on severity of symptoms, patient tolerance, and physician guidance.

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⚠️ Precautions and Warnings

• Use with caution in patients with:

  • Liver or kidney impairment

  • Seizure disorders

  • Known hypersensitivity to tolperisone or related compounds

• Not recommended during pregnancy or breastfeeding unless clearly needed

• May cause mild drowsiness or dizziness, so avoid operating heavy machinery until you know how it affects you

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🤒 Side Effects

Common:

• Drowsiness or light-headedness

• Headache

• Nausea, upset stomach

• Dry mouth

Rare but serious:

• Allergic reactions: rash, itching, swelling

• Hypotension (low blood pressure)

• Visual disturbances

• Muscle weakness (in rare cases)

Stop the medication and consult a doctor if severe side effects or signs of allergy occur.

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🔄 Drug Interactions

• May enhance the effects of CNS depressants, such as sedatives or alcohol

• Interaction with other muscle relaxants or anticholinergic drugs

• Should not be taken with MAO inhibitors

Always inform your doctor about all medications and supplements you are taking.

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🧊 Storage Instructions

• Store at 15–25°C in a dry place, away from sunlight and moisture

• Keep out of reach of children

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📝 Conclusion

Tolperisone 450mg offers effective relief from muscle stiffness and spasms without the excessive sedation associated with other muscle relaxants. Its central action, favorable safety profile, and tolerability make it a valuable part of therapy for spasticity, especially in neurological and musculoskeletal disorders. When used under medical guidance, it improves mobility, reduces discomfort, and enhances quality of life.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.