Description
🌟 DUAL RELIEF COMBO TABLET 🌟
Powerful Solution for Migraine, Pain & Nausea Relief
💊 Composition (Per Tablet)
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Naproxen – 500 mg
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Domperidone – 10 mg
🧠 Overview
This dual-action tablet combines Naproxen, a potent nonsteroidal anti-inflammatory drug (NSAID), with Domperidone, an effective antiemetic and prokinetic agent. It is specially designed to relieve moderate to severe pain—particularly migraine and menstrual pain—alongside associated symptoms like nausea and vomiting. This makes it ideal for treating pain conditions with a gastrointestinal component.
🔬 Mechanism of Action
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Naproxen:
A widely used NSAID that exerts its effects by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for prostaglandin production. By reducing prostaglandins, Naproxen alleviates pain, inflammation, and fever, making it effective in treating migraine, musculoskeletal pain, dysmenorrhea, and other inflammatory conditions. -
Domperidone:
A dopamine D2 receptor antagonist that acts on the chemoreceptor trigger zone (CTZ) in the brain to prevent nausea and vomiting. It also enhances gastrointestinal motility, helping to clear the stomach and support better drug absorption, which is particularly useful during migraine attacks when delayed gastric emptying is common.
🎯 Indications
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Acute migraine attacks (with or without aura)
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Nausea and vomiting associated with pain or migraine
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Dysmenorrhea (painful menstruation)
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Postoperative pain and nausea
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Pain with gastrointestinal discomfort
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Tension headaches with gastric upset
✅ Key Benefits
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Dual-action approach: Treats pain and its common companion symptom—nausea
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Fast-acting: Rapid absorption with enhanced gastric motility
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Reduces gastric irritation commonly caused by NSAIDs alone
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Improves patient compliance during migraine or pain flare-ups
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Helps manage functional GI symptoms associated with pain episodes
💊 Dosage & Administration
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Adults:
1 tablet twice daily, preferably after meals, or as prescribed by a physician -
Duration: Short-term use is recommended (usually 3–5 days)
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Pediatric use: Not typically recommended; to be used only under specialist supervision
⚠️ Precautions & Side Effects
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Common Side Effects:
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Gastric discomfort
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Drowsiness
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Dry mouth
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Headache
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Serious (Rare):
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Gastrointestinal bleeding
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Renal impairment
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QT interval prolongation (Domperidone-related)
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Allergic reactions
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Contraindications:
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History of peptic ulcers or GI bleeding
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Cardiac arrhythmias or QT prolongation
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Severe liver or kidney disease
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Pregnancy and breastfeeding (unless deemed essential by a physician)
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Drug Interactions:
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Avoid combining with other NSAIDs or corticosteroids
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Monitor when using with CYP3A4 inhibitors or drugs affecting cardiac rhythm
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🛡️ Storage
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Store in a cool, dry place below 25°C
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Protect from moisture and direct sunlight
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Keep out of reach of children
📝 Conclusion
This Naproxen + Domperidone combination offers comprehensive symptom control for patients experiencing both pain and nausea, especially in migraine, menstrual cramps, or post-operative recovery. Its synergistic effect not only improves patient comfort but also enhances treatment effectiveness by ensuring better drug absorption and symptom relief.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
