🧠🔥💊 Pregabalin 75mg + Nortriptyline 10mg + Methylcobalamin 1500mcg Tablet: Triple Action Relief for Neuropathic Pain
This fixed-dose combination of Pregabalin 75mg, Nortriptyline 10mg, and Methylcobalamin (Vitamin B12) 1500mcg offers a comprehensive approach to treating neuropathic pain, a chronic condition caused by nerve damage due to diabetes, spinal injuries, shingles, or neurological disorders. Each component works synergistically to relieve nerve pain, stabilize mood, and support nerve repair, making this combination a powerful therapy for long-term pain control and nerve health.
🔬 Mechanism of Action
🔹 Pregabalin 75mg
An analog of GABA, Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters like glutamate and substance P, thereby:
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Decreasing nerve signal transmission
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Relieving neuropathic pain
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Reducing anxiety symptoms
🔹 Nortriptyline 10mg
A tricyclic antidepressant (TCA) that works by inhibiting the reuptake of norepinephrine and serotonin, helping to modulate pain pathways in the central nervous system. Benefits include:
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Enhancement of pain inhibition
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Mood stabilization
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Useful in depression linked to chronic pain
🔹 Methylcobalamin 1500mcg
An active form of Vitamin B12, crucial for:
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Nerve cell regeneration
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Myelin sheath repair
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Improved nerve conduction
It supports long-term nerve healing and may help reverse neuropathic damage over time.
📌 Indications and Uses
This triple combination is indicated for:
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Diabetic peripheral neuropathy
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Post-herpetic neuralgia (after shingles)
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Sciatica
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Chronic low back pain with nerve involvement
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Fibromyalgia
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Trigeminal neuralgia
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Alcoholic neuropathy
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Vitamin B12 deficiency with neurological symptoms
It’s a preferred choice in patients who suffer from nerve pain along with anxiety, sleep disturbances, or mood changes.
💊 Dosage and Administration
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Usual adult dose: One tablet once or twice daily, depending on severity and tolerance
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Best taken after meals, to reduce gastric discomfort
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Dosage may be adjusted gradually based on clinical response and tolerability
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Long-term use may be required in chronic cases, under medical supervision
⚠️ Precautions and Warnings
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Avoid in patients with:
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Hypersensitivity to any of the components
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Severe renal impairment (Pregabalin dose may need adjustment)
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Cardiac disorders (caution with Nortriptyline)
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Caution in:
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Elderly patients
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Patients with glaucoma or urinary retention
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Avoid alcohol and CNS depressants while on this medication
🤒 Side Effects
Common:
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Dizziness
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Drowsiness
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Dry mouth
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Weight gain
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Constipation
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Blurred vision
Serious:
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Mood changes or suicidal thoughts (rare)
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Cardiac rhythm disturbances (Nortriptyline)
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Allergic reactions (rash, itching, swelling)
Seek immediate medical help for chest pain, suicidal ideation, or breathing difficulty.
🔄 Drug Interactions
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Increased sedation with alcohol, benzodiazepines, opioids
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May interact with MAO inhibitors, SSRIs, and antiarrhythmic drugs
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Monitor when used with antihypertensives (may enhance hypotension)
🧊 Storage Instructions
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Store at 15–25°C, in a dry place, away from sunlight
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Keep away from children and pets
📝 Conclusion
The combination of Pregabalin + Nortriptyline + Methylcobalamin provides comprehensive relief from neuropathic pain, addressing both symptom control and nerve repair. Its triple-action formula tackles pain signals, supports mood balance, and promotes nerve healing, making it highly effective for chronic nerve-related conditions.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
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