💊 Ofloxacin 200 mg + Ornidazole 500 mg Tablet

Dual-Action Antibacterial & Antiprotozoal Therapy for Gastrointestinal and Genitourinary Infections

---

🔍 Overview

Ofloxacin 200 mg + Ornidazole 500 mg Tablet is a broad-spectrum antimicrobial combination used to treat various bacterial and protozoal infections, especially in the gastrointestinal and urogenital tracts. It is effective against organisms causing diarrhea, dysentery, vaginal infections, and certain dental or postoperative infections.

---

💡 Active Ingredients & Mechanism

• Ofloxacin 200 mg
  A fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, and repair. Effective against Gram-positive and Gram-negative bacteria.

• Ornidazole 500 mg
  A nitroimidazole derivative with antiprotozoal and antibacterial properties. It acts by damaging DNA in anaerobic organisms and protozoa (e.g., Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis), leading to cell death.

---

📌 How to Use

• Dosage:
  Typically 1 tablet twice daily after meals for 5–7 days, or as prescribed by a healthcare professional.

• Administration:

  • Take with or after food to minimize gastrointestinal discomfort

  • Swallow whole with water; do not crush or chew

• Duration: Complete the full course even if symptoms improve early to prevent resistance and relapse.

---

✅ Common Indications

• Acute and chronic diarrhea or dysentery (bacterial or protozoal origin)

• Amoebiasis (intestinal or hepatic)

• Giardiasis

• Trichomoniasis and other vaginal infections

• Urinary tract infections (UTIs)

• Dental infections and postoperative infections involving anaerobes

---

⚠️ Common Side Effects

• Nausea or vomiting

• Headache

• Metallic taste in mouth

• Dizziness or fatigue

• Stomach discomfort or bloating

• Dry mouth

These are generally mild and resolve on their own with continued use or after completion of therapy.

---

🚨 Serious Side Effects (Rare but Critical)

• Tendon rupture or inflammation (fluoroquinolone-related; more common in elderly)

• Seizures or convulsions (especially in patients with CNS disorders)

• Peripheral neuropathy (numbness, tingling, or weakness in limbs)

• Liver enzyme elevation or hepatitis

• Severe allergic reactions – rash, swelling, itching, or breathing difficulties

• QT prolongation – abnormal heart rhythm in predisposed individuals

Seek medical attention immediately if any of these occur.

---

🩺 Monitoring & Follow-Up

• Baseline Evaluation:

  • Assess liver and kidney function in patients with chronic illness

  • ECG in patients at risk for QT prolongation (e.g., elderly, heart disease)

• During Therapy:

  • Monitor for signs of CNS effects, allergic reactions, or tendon pain

  • Re-evaluate therapy if no improvement in 48–72 hours

---

⚠️ Warnings & Precautions

• Avoid alcohol during and for 48 hours after treatment (due to Ornidazole interaction)

• Use cautiously in:

  • Patients with epilepsy or CNS disorders

  • Elderly patients (higher risk of tendon and heart issues)

  • Pregnancy and breastfeeding – not recommended unless essential

• Avoid driving or machinery use if experiencing dizziness or drowsiness

• Not for viral infections (e.g., common cold, flu)

---

📝 Summary

Ofloxacin 200 mg + Ornidazole 500 mg Tablet is a powerful combination for treating mixed bacterial and protozoal infections, especially those affecting the gut and genitourinary tract. It provides broad-spectrum coverage and rapid symptom relief when used correctly.

Always follow your doctor’s advice, dosage instructions, and never self-medicate.