Description
🧪 Cefixime 100 mg + Ofloxacin 100 mg Tablets: Comprehensive Overview
Cefixime 100 mg + Ofloxacin 100 mg tablets are a fixed-dose combination antibiotic used to treat various bacterial infections. This combination leverages the strengths of two antibiotics: cefixime, a third-generation cephalosporin, and ofloxacin, a fluoroquinolone. Together, they offer broad-spectrum activity against a range of pathogens.
🧬 Composition & Mechanism of Action
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Cefixime (100 mg): Inhibits bacterial cell wall synthesis, leading to bacterial cell death.
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Ofloxacin (100 mg): Inhibits bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication, thus preventing bacterial cell division.
This combination provides a synergistic effect, enhancing antibacterial efficacy and broadening the spectrum of activity.
💊 Indications
Cefixime + Ofloxacin tablets are prescribed for:
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Urinary tract infections (UTIs)
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Typhoid fever
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Acute otitis media (ear infections)
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Upper and lower respiratory tract infections
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Gonorrhea
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Prostatitis
The combination is effective against both Gram-positive and Gram-negative bacteria.
⚠️ Common Side Effects
Most side effects are mild and may include:
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Diarrhea
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Nausea
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Dyspepsia (indigestion)
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Loose stools
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Abdominal pain
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Vomiting
These side effects often resolve with continued use or after discontinuation of the medication.
🚨 Serious Side Effects
Although rare, serious side effects may include:
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Severe allergic reactions (rash, itching, swelling of the face/lips/tongue)
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Tendonitis or tendon rupturePeripheral neuropathy (nerve damage)
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Seizures
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Clostridioides difficile-associated diarrhea
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Elevated liver enzymes
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Leukopenia or thrombocytopenia
Immediate medical attention is required if any of these occur.
🩺 Monitoring & Follow-Up
Regular monitoring may be necessary, especially for individuals with:
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Renal or hepatic impairment
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A history of gastrointestinal disorders
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Concurrent use of other medications
Periodic blood tests may be recommended to assess kidney and liver function and to monitor for any adverse effects.
⚠️ Warnings & Precautions
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Allergy: Avoid if allergic to cephalosporins, penicillins, or fluoroquinolones.
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Tendon Issues: Use with caution in elderly patients or those on corticosteroids due to the risk of tendonitis or tendon rupture.
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Seizure Disorders: Contraindicated in individuals with a history of seizures or central nervous system disorders.
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Diabetes: May cause hypoglycemia; monitor blood sugar levels closely.
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Pregnancy & Breastfeeding: Consult a healthcare provider before use during pregnancy or breastfeeding.
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Drug Interactions: Avoid combining with antacids, multivitamins, or dairy products, as they may reduce ofloxacin absorption. Use caution with anticoagulants like warfarin due to increased bleeding risk.
✅ Summary
Cefixime 100 mg + Ofloxacin 100 mg tablets are a potent combination antibiotic effective against a wide range of bacterial infections. While generally well-tolerated, it’s essential to use this medication under medical supervision, especially for individuals with pre-existing conditions or those taking other medications. Adhering to prescribed dosages and completing the full course of treatment are crucial to ensure effectiveness and reduce the risk of antibiotic resistance.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
