🌿 Omeprazole 20 mg + Domperidone 10 mg Tablet

Dual-Action Relief for Acid Reflux, Indigestion & Nausea

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🔍 Overview

Omeprazole 20 mg + Domperidone 10 mg Tablet is a combination medication used to treat acid reflux, indigestion, gastritis, GERD (gastroesophageal reflux disease), and bloating with nausea or vomiting. It combines a proton pump inhibitor (PPI) with a prokinetic antiemetic, offering both acid suppression and improved stomach emptying.

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💊 Active Ingredients & Mechanism

• Omeprazole 20 mg
  A proton pump inhibitor that blocks the H⁺/K⁺-ATPase enzyme in the stomach lining, reducing gastric acid secretion. It helps relieve heartburn, heal ulcers, and manage GERD.

• Domperidone 10 mg
  A dopamine D2 receptor antagonist that works as a prokinetic agent. It increases the movement of food through the stomach and intestines and prevents nausea and vomiting by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ).

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📌 How to Use

• Dosage:
  Typically 1 tablet once or twice daily before meals, or as directed by a physician.

• Administration:

  • Take 15–30 minutes before meals

  • Swallow whole with water — do not crush or chew

  • Avoid taking with acidic beverages (juice, soda)

• Course Duration: Short-term (4–8 weeks) for most patients unless advised otherwise

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✅ Common Indications

• Gastroesophageal reflux disease (GERD)

• Acid peptic disorders

• Functional dyspepsia (indigestion)

• Nausea and bloating due to delayed gastric emptying

• NSAID-induced gastritis or ulcers

• Heartburn with regurgitation

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⚠️ Common Side Effects

• Headache

• Abdominal pain

• Dry mouth

• Nausea or vomiting

• Diarrhea or constipation

• Flatulence

• Dizziness

These are usually mild and self-limiting.

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🚨 Serious Side Effects (Rare)

• Irregular heartbeat or QT prolongation (Domperidone-related)

• Galactorrhea or breast tenderness due to increased prolactin (Domperidone)

• Severe allergic reactions (rash, swelling, difficulty breathing)

• Liver dysfunction or elevated liver enzymes

• Low magnesium levels, especially with long-term use of Omeprazole

• Tremors or involuntary movements (rare extrapyramidal symptoms with Domperidone)

Seek medical attention if serious or persistent symptoms occur.

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🩺 Monitoring & Follow-Up

• Short-Term Use: Minimal monitoring if used for 2–4 weeks

• Long-Term Use:

  • Monitor electrolytes (especially magnesium, potassium)

  • ECG monitoring in patients at risk of QT prolongation

  • Check liver function if symptoms suggest hepatic issues

  • Review for prolactin-related effects (especially in women)

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⚠️ Warnings & Precautions

• Cardiac Risks: Domperidone may increase the risk of arrhythmias, especially in elderly or those with heart disease

• Avoid in patients with:

  • Known QT prolongation, heart failure, or electrolyte imbalances

  • Moderate to severe hepatic impairment

• Pregnancy & Lactation: Use only under medical supervision

• Not recommended with strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)

• Avoid alcohol — may worsen gastrointestinal irritation

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📝 Summary

Omeprazole 20 mg + Domperidone 10 mg Tablet offers effective dual therapy for acid-related and motility disorders. While Omeprazole reduces stomach acid, Domperidone promotes faster gastric emptying and prevents nausea. This combination improves symptoms like heartburn, bloating, and indigestion more effectively than either drug alone.

Always follow your doctor’s advice, dosage instructions, and never self-medicate.