PAZOM 40 TABLET

Description

💊 Pantoprazole 40mg Tablet – Targeted Acid Relief. Long-Lasting Protection.

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🔬 What is Pantoprazole 40mg?

Pantoprazole 40mg is a proton pump inhibitor (PPI) that reduces the production of stomach acid. It works by irreversibly blocking the H⁺/K⁺-ATPase enzyme (gastric proton pump) in the stomach lining, which is responsible for secreting hydrochloric acid.

This action makes it highly effective for treating acid-related gastrointestinal conditions, promoting healing of the digestive tract and providing long-term relief.

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✅ Uses / Indications

Pantoprazole 40mg is prescribed for the treatment and management of:

• Gastroesophageal reflux disease (GERD)

• Erosive esophagitis

• Peptic ulcers (gastric and duodenal)

• Zollinger-Ellison syndrome (acid hypersecretion)

• NSAID-induced ulcers

• Helicobacter pylori-associated ulcer treatment (in combination with antibiotics)

• Heartburn and acid indigestion (short-term use)

It is often used as a maintenance therapy in chronic reflux or ulcer-prone patients.

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🧪 Composition / Ingredients

Each enteric-coated tablet contains:

• Pantoprazole sodium sesquihydrate equivalent to 40mg of Pantoprazole

• Excipients may include:

  • Mannitol

  • Crospovidone

  • Sodium carbonate

  • Magnesium stearate

  • Hypromellose

  • Titanium dioxide

  • Methacrylic acid copolymer (for enteric coating)

The enteric coating ensures the drug bypasses stomach acid and dissolves in the small intestine for optimal effect.

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⚠️ Precautions and Warnings

• Liver dysfunction: Use with caution in patients with impaired liver function.

• Long-term use risks: May lead to vitamin B12 deficiency, magnesium deficiency, or osteoporosis-related fractures.

• Infection risk: Chronic acid suppression may increase risk of Clostridium difficile infection or pneumonia.

• Pregnancy and lactation: Considered safe in pregnancy (Category B), but consult a physician.

• Children: Use only in children when prescribed for specific conditions.

Do not crush or chew the tablet — it must remain intact for the enteric coating to function.

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💥 Side Effects

Common:

• Headache

• Diarrhea or constipation

• Nausea

• Flatulence

• Abdominal pain

Less Common but Serious:

• Low magnesium levels (muscle cramps, palpitations)

• Severe allergic reactions (rash, swelling, difficulty breathing)

• Liver enzyme changes

• Bone fractures (with prolonged high-dose use)

Report any unusual fatigue, muscle weakness, or seizures to your doctor.

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📋 Dosage and Administration

• Typical dose: One tablet (40mg) once daily, usually 30–60 minutes before breakfast.

• Duration of therapy depends on the condition:

  • GERD: 4 to 8 weeks

  • Ulcers: 4 to 8 weeks

  • Maintenance: Long-term as directed

• May be combined with antibiotics for H. pylori eradication.

Do not stop abruptly if taken long-term; taper as per doctor’s advice to avoid acid rebound.

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🔄 Drug Interactions

Pantoprazole may interact with:

• Clopidogrel – may reduce its antiplatelet effect

• Warfarin – monitor INR levels

• Methotrexate – levels may increase, especially in high doses

• HIV medications – may alter absorption (atazanavir, rilpivirine)

Avoid taking with antacids at the same time; space them at least 1 hour apart.

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📌 Conclusion

Pantoprazole 40mg offers potent, lasting relief from acid-related conditions like GERD, ulcers, and reflux. It’s well-tolerated and ideal for both acute symptom relief and long-term management. Like all PPIs, it should be used under medical supervision to avoid nutrient deficiencies and potential complications.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.