PENTANERV NT TABLET

Gabapentin 100mg + Nortriptyline 10mg Tablet

Combination Therapy for Neuropathic Pain Relief

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🔬 What Is It?

Gabapentin 100mg + Nortriptyline 10mg is a combination medication primarily used for the treatment of neuropathic pain — a chronic pain condition resulting from nerve damage due to diabetes, shingles, or spinal injuries. It combines the effects of two different drug classes for enhanced pain relief and nerve repair.

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💊 Active Ingredients and How They Work

1. Gabapentin (100mg)

   • Class: Anticonvulsant

   • Action: Stabilizes nerve activity and decreases abnormal excitement in the brain, which helps in managing nerve pain and seizures.

2. Nortriptyline (10mg)

   • Class: Tricyclic antidepressant (TCA)

   • Action: Inhibits the reuptake of norepinephrine and serotonin, increasing their levels and modifying the way nerves perceive pain.

Together, these agents synergistically reduce pain signals and improve the patient’s quality of life.

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🧾 How to Use

• Dosage: As prescribed by your doctor, usually once or twice daily.

• Administration: Take with or without food. Swallow whole with water.

• Duration: Long-term use may be needed for chronic conditions, but regular assessment is essential.

Do not suddenly stop the medication without medical advice, as withdrawal symptoms may occur.

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⚠️ Common Side Effects

• Drowsiness or dizziness

• Dry mouth

• Constipation

• Weight gain

• Blurred vision

• Fatigue

These effects are generally mild and may decrease with continued use.

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🚨 Serious Side Effects (Seek Immediate Help)

• Suicidal thoughts or mood changes

• Severe allergic reactions (rash, itching, swelling, trouble breathing)

• Unusual bleeding or bruising

• Difficulty urinating or irregular heartbeat

• Severe confusion or hallucinations

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🩺 Monitoring & Follow-Up

Regular follow-up visits are important to:

• Evaluate response to therapy (pain scores, mood, sleep)

• Monitor side effects, especially in the elderly

• Check kidney and liver function, especially with long-term use

• Assess for signs of depression or suicidal ideation

• Adjust dosage based on clinical need and tolerability

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⚠️ Warnings & Precautions

• Avoid alcohol: Increases risk of drowsiness and dizziness.

• Use with caution in elderly patients due to fall risk.

• Not recommended during pregnancy unless clearly needed.

• Avoid driving or machinery until you know how it affects you.

• May interact with CNS depressants, anticholinergics, or other antidepressants.

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📝 Summary

Gabapentin 100mg + Nortriptyline 10mg is a powerful combination therapy used for neuropathic pain, offering benefits from both nerve-calming and mood-stabilizing mechanisms. It is effective and generally well-tolerated, but must be used under careful medical supervision. Monitor for both therapeutic benefit and side effects, and follow all medical advice for dose adjustments and lifestyle precautions.

Always follow your doctor’s advice, dosage instructions, and never self-medicate.