๐ง โก๐ Pregabalin 75mg Capsule: Neuropathic Pain & Nerve Stabilizer
Pregabalin 75mg is a prescription medication used to treat neuropathic pain, epilepsy, and generalized anxiety disorder (GAD). It belongs to the class of drugs called anticonvulsants or neuromodulators, specifically designed to calm overactive nerves. Pregabalin is a structural derivative of gamma-aminobutyric acid (GABA) but does not act directly on GABA receptors. Instead, it modulates calcium channel activity, reducing the release of neurotransmitters that cause nerve pain, seizures, and anxiety.
This doseโ75mgโis commonly used as a starting or maintenance dose, especially for treating nerve-related pain or partial-onset seizures.
๐ฌ Mechanism of Action
Pregabalin binds to the ฮฑ2-ฮด subunit of voltage-gated calcium channels in the central nervous system. This:
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Reduces the release of excitatory neurotransmitters like glutamate, noradrenaline, substance P, and calcitonin gene-related peptide (CGRP)
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Stabilizes nerve signaling
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Helps relieve pain, reduce seizure frequency, and lower anxiety
Although similar in action to gabapentin, pregabalin has better bioavailability and faster onset of action.
๐ Indications and Uses
Pregabalin 75mg is approved and used for:
๐น Neuropathic Pain
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Diabetic peripheral neuropathy
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Post-herpetic neuralgia (pain following shingles)
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Spinal cord injury-induced nerve pain
๐น Epilepsy
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As adjunctive therapy for partial-onset seizures (with or without secondary generalization)
๐น Generalized Anxiety Disorder (GAD)
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To relieve persistent and excessive worry, restlessness, or tension (approved in some countries)
๐น Fibromyalgia
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Helps manage widespread muscle pain and fatigue (off-label in some regions)
๐ Dosage and Administration
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Initial dose: 75mg twice daily (150mg/day total)
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May be increased to a maximum of 300โ600mg/day, based on condition and tolerability
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Take with or without food, at the same time daily
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Capsules should be swallowed whole with water
Dose adjustment is necessary in patients with renal impairment.
โ ๏ธ Precautions and Warnings
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CNS effects: May cause drowsiness, dizziness, or blurred visionโavoid driving or operating machinery until effects are known
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Tapering is essential: Do not stop suddenly; reduce gradually to prevent withdrawal symptoms
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Use with caution in:
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Elderly
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Patients with heart failure or renal dysfunction
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Risk of abuse, misuse, and dependence, especially with history of substance use
๐ค Side Effects
Common:
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Dizziness
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Drowsiness or fatigue
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Dry mouth
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Weight gain
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Swelling in hands or feet (edema)
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Blurred vision
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Difficulty concentrating
Less common but serious:
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Suicidal thoughts or behavior
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Allergic reactions (rash, itching, breathing difficulty)
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Withdrawal symptoms (insomnia, nausea, headache)
๐ Drug Interactions
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Increases sedation when used with alcohol, opioids, benzodiazepines, or other CNS depressants
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No significant interaction with most other antiepileptic drugs
๐ง Storage Instructions
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Store at 15โ30ยฐC, in a dry place away from light
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Keep out of reach of children
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Do not use after expiration date
๐ Conclusion
Pregabalin 75mg is an effective and well-tolerated option for nerve pain relief, seizure control, and anxiety management. With its fast onset, good absorption, and broad therapeutic uses, it helps improve quality of life for patients with chronic neurological conditions. Careful dosing and monitoring ensure safe, long-term symptom control.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult your healthcare provider for personalized recommendations.
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