Description
🌟 Acid Control & Motility Support Capsule
(Rabeprazole 20mg + Domperidone 30mg)
🔍 What Is This Medication Combination?
The Rabeprazole 20mg + Domperidone 30mg capsule is a fixed-dose combination used to treat acid reflux (GERD), dyspepsia, heartburn, bloating, and nausea related to delayed gastric emptying. It offers dual action by reducing stomach acid and improving gastrointestinal motility.
Ingredients:
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Rabeprazole 20mg
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A proton pump inhibitor (PPI) that blocks the H⁺/K⁺-ATPase pump in stomach lining cells, leading to reduced gastric acid production.
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Used to treat GERD, peptic ulcers, Zollinger-Ellison syndrome, and NSAID-induced gastritis.
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Domperidone 30mg
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A prokinetic and antiemetic agent that blocks dopamine D₂ receptors in the gut and the chemoreceptor trigger zone (CTZ).
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Increases gastrointestinal motility, enhances gastric emptying, and relieves nausea and vomiting.
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💊 How to Use This Capsule
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Dosage: Typically once daily, 15–30 minutes before a meal, or as directed by a physician.
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Route: Oral, swallow whole with water (do not crush or chew).
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Course Duration: Short-term (2–8 weeks), or longer if prescribed for chronic conditions.
⚠️ Common Side Effects
Usually mild and self-limiting:
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Rabeprazole:
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Headache
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Constipation or diarrhea
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Flatulence
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Abdominal discomfort
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Domperidone:
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Dry mouth
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Drowsiness or dizziness
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Fatigue
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Mild breast tenderness or menstrual irregularities (due to increased prolactin)
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🚨 Serious Side Effects (Seek Immediate Medical Attention)
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Rabeprazole:
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Low magnesium: Muscle cramps, palpitations, seizures
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Clostridioides difficile infection (chronic diarrhea)
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Vitamin B12 deficiency (with long-term use)
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Bone fractures (long-term PPI use)
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Domperidone:
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QT interval prolongation (risk of arrhythmias, especially in cardiac patients)
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Gynecomastia or galactorrhea due to elevated prolactin
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Extrapyramidal symptoms (very rare)
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🔍 Monitoring & Follow-Up
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Short-Term:
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Symptom resolution (heartburn, nausea, bloating)
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Tolerance to medication
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Long-Term:
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Serum magnesium, calcium, and vitamin B12 if used >3 months
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ECG monitoring in patients with cardiac risk or concurrent QT-prolonging drugs
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Prolactin levels if hormonal side effects occur
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Liver function tests in prolonged use or if hepatotoxicity is suspected
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⚠️ Warnings & Precautions
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Use in elderly: Higher risk of arrhythmias and electrolyte imbalance.
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Cardiac conditions: Domperidone may prolong QT interval—use cautiously.
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Renal/hepatic impairment: Adjust dosage or monitor more frequently.
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Pregnancy & lactation: Use only if clearly necessary; consult a doctor.
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Drug Interactions:
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Rabeprazole can affect absorption of pH-dependent drugs (e.g., ketoconazole, iron)
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Domperidone interacts with antifungals, macrolides, and QT-prolonging medications.
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✅ Summary
The Rabeprazole 20mg + Domperidone 30mg capsule is an effective combination therapy for acid-related and functional gastrointestinal disorders. Rabeprazole reduces stomach acid, while Domperidone enhances gastric motility and relieves nausea. This synergistic combo improves symptoms like bloating, indigestion, reflux, and gastric discomfort, especially when caused by delayed gastric emptying. While generally well tolerated, it requires careful monitoring, especially for cardiac, neurological, or hormonal side effects in long-term use. Always use under medical supervision.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
