ROZUCOR F 20 TABLET

Description

Description

Rosuvastatin 20mg + Fenofibrate 160mg is a fixed-dose combination medication used to manage mixed dyslipidemia—a condition involving elevated levels of both cholesterol and triglycerides. This combination is particularly effective in patients who have not responded adequately to monotherapy and are at high risk of cardiovascular disease.

Rosuvastatin (20mg)

Rosuvastatin is a potent statin that works by inhibiting the HMG-CoA reductase enzyme, which the liver uses to produce cholesterol. It:

• Reduces LDL (bad cholesterol)

• Increases HDL (good cholesterol)

• Lowers triglyceride levels (moderately)

It is effective in slowing the progression of atherosclerosis, thereby reducing the risk of heart attacks and strokes.

Fenofibrate (160mg)

Fenofibrate belongs to the class of medications known as fibrates. It primarily works by:

• Activating PPAR-α receptors, which increases the breakdown and elimination of triglycerides

• Reducing very low-density lipoproteins (VLDL)

• Raising HDL (good cholesterol)

Together, Rosuvastatin and Fenofibrate offer a dual-action lipid-lowering effect, providing comprehensive management of cholesterol and triglyceride imbalances.

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Safety Advice

1. Prescription-Only Use

This combination should be taken only under medical supervision, especially because both components affect the liver and muscles. The dose is typically tailored to individual lipid profiles and cardiovascular risk factors.

2. Who Should Not Use This Combination?

Avoid this medication if you have:

• Active liver disease or persistently abnormal liver function tests

• Severe kidney impairment

• Gallbladder disease

• Pregnancy or breastfeeding

• Known hypersensitivity to statins or fibrates

• History of muscle disorders related to statins or fibrates

3. Common Side Effects

Rosuvastatin may cause:

• Muscle pain or cramps

• Headache

• Abdominal discomfort

• Elevated liver enzymes

Fenofibrate may cause:

• Stomach upset

• Back pain

• Increased liver enzymes

• Mild rash or dizziness

These effects are usually mild but should be monitored if persistent.

4. Serious Side Effects (Seek Immediate Help)

• Rhabdomyolysis: severe muscle pain, weakness, dark urine

• Liver damage: yellowing of skin/eyes, fatigue, dark urine

• Pancreatitis: upper abdominal pain radiating to the back

• Kidney problems: decreased urination, swelling

5. Drug Interactions

Avoid combining with:

• Other statins or fibrates

• Blood thinners like warfarin (increased bleeding risk)

• Immunosuppressants (e.g., cyclosporine)

• Certain antibiotics and antifungals

• Alcohol (increases liver and muscle damage risk)

Always inform your doctor of all medications, vitamins, and supplements you are using.

6. Lifestyle and Monitoring

• Follow a low-fat, heart-healthy diet

• Exercise regularly

• Stop smoking and limit alcohol intake

• Routine blood tests for lipid levels, liver function, and muscle enzymes (CK) are recommended

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Storage Instructions

• Store at room temperature (15–25°C or 59–77°F)

• Keep in a cool, dry place, away from direct sunlight and moisture

• Do not refrigerate or freeze

• Store in the original blister pack or container

• Keep out of reach of children and pets

Do not use if the tablets are discolored, broken, or past their expiration date.

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Conclusion

Rosuvastatin 20mg + Fenofibrate 160mg offers a powerful combination therapy for patients with mixed dyslipidemia, significantly reducing the risk of cardiovascular events. When used under medical supervision with regular monitoring and lifestyle changes, it can be a safe and effective treatment to manage complex lipid disorders.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.