Description
💊🧴 Silodosin 4mg + Dutasteride 0.5mg
Dual-Action Relief for Benign Prostatic Hyperplasia (BPH)
Your complete guide to combination prostate therapy
Overview
Silodosin 4mg + Dutasteride 0.5mg is a combination therapy used in the treatment of benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate gland. This dual-medication approach addresses both immediate symptom relief and long-term prostate size reduction, making it highly effective for men experiencing moderate to severe urinary symptoms associated with BPH.
How It Works
🔹 Silodosin 4mg is a selective alpha-1A adrenergic receptor blocker. It relaxes the smooth muscles of the bladder neck and prostate, improving urine flow and relieving symptoms such as hesitancy, weak stream, and frequent urination.
🔹 Dutasteride 0.5mg is a 5-alpha reductase inhibitor. It blocks the conversion of testosterone into dihydrotestosterone (DHT), the hormone primarily responsible for prostate growth. Over time, this shrinks the prostate and prevents further enlargement.
Together, they offer both rapid symptom control (via Silodosin) and prostate volume reduction (via Dutasteride).
Indications
✅ Treatment of moderate to severe BPH symptoms, especially in:
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Men with enlarged prostates
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Those at risk of urinary retention or prostate-related surgery
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Patients seeking both short- and long-term relief
Dosage and Administration
💊 Usual Dose:
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1 capsule containing Silodosin 4mg + Dutasteride 0.5mg taken once daily, preferably with food
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Swallow whole; do not crush or chew
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Continue use as prescribed, even if symptoms improve early
Composition
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Active Ingredients:
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Silodosin – 4 mg
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Dutasteride – 0.5 mg
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Common Inactive Ingredients:
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Lactose monohydrate
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Cellulose derivatives
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Gelatin (capsule shell)
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Titanium dioxide
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Side Effects
🧾 Common:
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Retrograde ejaculation
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Decreased libido
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Erectile dysfunction
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Dizziness or light-headedness
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Breast tenderness or enlargement
⚠️ Less Common / Serious:
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Allergic reactions (rash, swelling, difficulty breathing)
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Depression or mood changes
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Liver function abnormalities
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Increased risk of high-grade prostate cancer (rare, under study)
Precautions
⚠️ Important considerations:
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Not for use in women or children
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Pregnant women should not handle capsules (dutasteride can be absorbed through the skin and harm a male fetus)
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Inform your doctor about liver issues, history of low blood pressure, or plans for cataract surgery (due to Silodosin)
Drug Interactions
🔄 Use with caution alongside:
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CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
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Other alpha-blockers or blood pressure medications
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PDE5 inhibitors (e.g., sildenafil)
Storage
📦 Store in a cool, dry place (20–25°C)
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Protect from light and moisture
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Keep out of reach of children
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Wash hands after handling capsules
Conclusion
Silodosin 4mg + Dutasteride 0.5mg is a powerful combination therapy offering both quick symptom relief and long-term prostate management for men with BPH. By combining the benefits of an alpha-blocker and a 5-alpha reductase inhibitor, this treatment helps improve urinary function, shrink prostate size, and reduce the need for surgery or acute urinary retention.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
