SINADOM TABLET

🌀💊🧠 Domperidone 15mg + Cinnarizine 20mg Tablet: Dual Action Relief for Nausea, Vomiting & Vertigo

The combination of Domperidone 15mg and Cinnarizine 20mg provides a powerful synergistic treatment for conditions like vertigo, motion sickness, nausea, vomiting, and inner ear balance disorders. This fixed-dose tablet targets both the vestibular system (balance center) and the gastrointestinal tract, offering fast and comprehensive symptom relief in patients experiencing dizziness with gastric discomfort.

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🔬 Mechanism of Action

🔹 Domperidone (15mg) – Prokinetic & Antiemetic

• A dopamine D2 receptor antagonist that works on the chemoreceptor trigger zone (CTZ) in the brain.

• Prevents nausea and vomiting by blocking dopamine receptors outside the blood-brain barrier.

• Promotes gastric emptying and enhances gut motility, reducing bloating and indigestion symptoms often associated with vertigo or motion sickness.

🔹 Cinnarizine (20mg) – Antihistamine with Calcium Channel Blocking Properties

• Blocks histamine H1 receptors and calcium channels in the vestibular apparatus of the inner ear, reducing abnormal nerve signals that cause vertigo, tinnitus, and balance issues.

• Also has mild anti-nausea and anti-vomiting effects.

• Particularly effective for labyrinthitis, Ménière’s disease, and motion sickness.

Together, these ingredients tackle both central (vestibular) and gastrointestinal causes of nausea and vertigo.

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📌 Indications and Uses

This combination is especially effective in:

• Vertigo of central or peripheral origin

• Ménière’s disease

• Labyrinthitis and vestibular neuritis

• Motion sickness and travel-induced nausea

• Postoperative or medication-induced nausea and dizziness

• Gastro-vestibular conditions where nausea and vertigo coexist

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💊 Dosage and Administration

• Typical adult dose: One tablet 1–3 times a day, preferably before meals

• Should be swallowed whole with water

• Duration of therapy depends on the severity and origin of the condition

Important: Long-term use should be avoided unless specifically advised by a doctor.

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⚠️ Precautions and Warnings

• Domperidone may affect heart rhythm (QT prolongation), especially at high doses or in elderly patients

• Cinnarizine may cause drowsiness; avoid driving or operating heavy machinery

• Caution in:

  • Patients with cardiac issues, liver dysfunction, or Parkinson’s disease

  • Pregnant or breastfeeding women – only under medical supervision

• Avoid alcohol as it may increase sedation

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🤒 Side Effects

Common:

• Drowsiness

• Dry mouth

• Fatigue

• Headache

• Mild abdominal cramps

Less common/serious:

• Irregular heartbeat (due to Domperidone)

• Extrapyramidal symptoms (rare with Domperidone)

• Allergic skin reactions

• Weight gain or increased appetite (long-term use)

Seek immediate attention if you experience palpitations, severe dizziness, or allergic reactions.

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🔄 Drug Interactions

• Increased risk of QT prolongation with ketoconazole, erythromycin, and fluconazole

• Avoid with other sedatives or alcohol

• May interact with antidepressants, antifungals, or antipsychotics

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🧊 Storage Instructions

• Store at 15–30°C, in a dry, cool place

• Keep away from sunlight and moisture

• Keep out of reach of children

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📝 Conclusion

Domperidone 15mg + Cinnarizine 20mg tablet is a safe, effective dual therapy for controlling vertigo, dizziness, and nausea, especially when caused by vestibular disorders or motion. Its dual mechanism targets both inner ear balance disturbances and gastric discomfort, offering comprehensive symptom relief with minimal sedation when used correctly under medical guidance.