Description
Dual-Action Relief for Nausea, Vomiting & Vertigo
💊 Composition (Per Tablet)
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Domperidone: 15 mg
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Cinnarizine: 20 mg
🧠 Overview
MOTIVERT-C™ is a powerful prokinetic-vestibular suppressant combination designed to treat nausea, vomiting, dizziness, and vertigo associated with both gastrointestinal and vestibular disorders. It combines the dopamine antagonist Domperidone with the antihistamine and calcium channel blocker Cinnarizine to provide broad-spectrum relief for symptoms arising from gastric stasis and inner ear disturbances.
🔬 Mechanism of Action
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Domperidone:
A peripherally acting dopamine D2 receptor antagonist, Domperidone enhances gastrointestinal motility and accelerates gastric emptying, thereby relieving symptoms of nausea and vomiting. It does not readily cross the blood-brain barrier, minimizing central nervous system side effects. -
Cinnarizine:
A histamine H1 receptor blocker and calcium channel modulator, Cinnarizine improves microcirculation in the vestibular system and dampens abnormal nerve signals, reducing dizziness, vertigo, and balance disturbances.
Together, these agents provide synergistic control over both central and peripheral triggers of nausea and vertigo.
🎯 Indications
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Motion sickness
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Vertigo of peripheral or central origin
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Meniere’s disease
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Vestibular neuritis
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Gastric dysmotility-induced nausea
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Post-operative nausea and vomiting (PONV)
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Gastroesophageal reflux-associated vomiting
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Chemotherapy- or medication-induced nausea
✅ Key Benefits
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Dual mechanism: targets vestibular imbalance and GI dysmotility
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Fast relief from dizziness, nausea, and vomiting
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Non-sedating profile with Domperidone
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Suitable for use in both acute and chronic conditions
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Improves quality of life in patients with mixed vestibulo-gastric symptoms
💡 Dosage & Administration
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Adults: 1 tablet two to three times daily before meals
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Should be taken 15–30 minutes prior to food for optimal efficacy
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Dosage should be adjusted based on clinical need and physician discretion
⚠️ Precautions & Side Effects
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Common side effects: dry mouth, headache, drowsiness, mild gastrointestinal discomfort
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Domperidone may cause QT prolongation in susceptible individuals — caution in cardiac patients
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Not recommended in patients with prolactin-secreting tumors, severe hepatic impairment, or known cardiac arrhythmias
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Use in pregnancy and lactation only if clearly needed and under medical supervision
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Avoid use with drugs that prolong QT interval or inhibit CYP3A4
🛡️ Storage
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Store at a temperature below 25°C
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Protect from light and moisture
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Keep out of reach of children
📝 Conclusion
MOTIVERT-C™ Tablet offers a comprehensive approach to managing nausea and vertigo by addressing both gastrointestinal dysmotility and vestibular dysfunction. Its dual-action formula ensures faster symptom relief, improved patient comfort, and enhanced compliance—making it a valuable choice for patients experiencing multi-origin nausea and dizziness.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
