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SOLPRATE CR 500 TABLET

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VALPARIN CHRONO 500 TABLET

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SOVAL CHRONO 500 TABLET

Original price was: ₹103.90.Current price is: ₹88.32.

SOVAL CHRONO 500 TABLET

Sodium Valproate 333mg + Valproic Acid 145mg

Shine Pharmaceuticals Ltd

Description

Description

🧠⚡💊 Sodium Valproate 333mg + Valproic Acid 145mg Tablet: High-Strength Control for Epilepsy & Mood Disorders

The combination of Sodium Valproate 333mg and Valproic Acid 145mg delivers a total valproate equivalent of 500mg, making it a high-strength formulation ideal for the treatment of moderate to severe epilepsy, bipolar disorder, and migraine prophylaxis. This dual-action formulation provides both immediate and sustained release, offering superior control over seizures and mood fluctuations in various neurological and psychiatric conditions.


🔬 Mechanism of Action

Sodium Valproate and Valproic Acid work synergistically to increase the concentration of gamma-aminobutyric acid (GABA) in the brain—a key inhibitory neurotransmitter responsible for calming neuronal activity. The mechanism includes:

  • Enhancement of GABA synthesis

  • Inhibition of GABA breakdown

  • Blocking of voltage-gated sodium and T-type calcium channels, stabilizing nerve activity

This combination exerts a broad-spectrum antiepileptic effect and also works as a central mood stabilizer.


📌 Indications and Uses

This 500mg total valproate tablet is used in:

  • Epilepsy:

    • Generalized tonic-clonic seizures

    • Absence seizures

    • Myoclonic seizures

    • Partial (focal) seizures

    • Mixed seizure types

  • Bipolar disorder:

    • Acute manic episodes

    • Long-term mood stabilization

  • Migraine prophylaxis

  • Impulse control disorders, aggression, or behavioral issues in neurological conditions (off-label)

It is suitable for adults and adolescents who need higher therapeutic doses in a convenient single-tablet form.


💊 Dosage and Administration

  • Starting dose: Usually 10–15 mg/kg/day; titrated to 30–60 mg/kg/day

  • For bipolar disorder: 750–1500 mg/day, adjusted by response

  • Migraine prevention: 500–1000 mg/day

  • Tablet should be taken after meals to minimize gastrointestinal discomfort

  • Doses should be divided throughout the day unless using an extended-release form

👩‍⚕️ Always follow physician’s dosage recommendation, especially during titration.


⚠️ Precautions and Warnings

  • Liver function must be closely monitored, especially in the first 6 months

  • Contraindicated in:

    • Liver disease

    • Known urea cycle disorders

    • Pregnancy, due to high teratogenic risk (e.g., neural tube defects, cognitive delays)

  • Use cautiously in:

    • Children under 2 years

    • Patients with renal impairment

    • Individuals with bleeding disorders

Regular monitoring of liver enzymes, complete blood count, and serum ammonia levels is recommended.


🤒 Side Effects

Common:

  • Nausea, indigestion

  • Drowsiness, tremor

  • Weight gain

  • Temporary hair loss

Serious (seek immediate medical attention):

  • Hepatotoxicity

  • Pancreatitis

  • Severe allergic reactions

  • Thrombocytopenia or bleeding

  • Hyperammonemic encephalopathy


🔄 Drug Interactions

  • May potentiate effects of Lamotrigine, Phenytoin, Phenobarbital

  • May increase bleeding risk when taken with anticoagulants

  • Avoid alcohol and other CNS depressants

  • Can affect hormonal contraceptives and should be discussed with a healthcare provider


🧊 Storage Instructions

  • Store at 15–30°C, in a cool, dry place

  • Protect from light and moisture

  • Keep out of reach of children


📝 Conclusion

Sodium Valproate 333mg + Valproic Acid 145mg offers robust, high-dose therapy for managing complex seizure disorders and mood instability. Its broad-spectrum action, dual pharmacokinetics, and effectiveness in multiple indications make it a go-to medication in neurological and psychiatric care. With careful monitoring and adherence, it offers long-term control and improved quality of life.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.

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