TELPRES CT 40/6.25 TABLET

Description

💊 Telmisartan 40mg + Chlorthalidone 6.25mg Tablet

Smart Dual Therapy for Gentle & Sustained Blood Pressure Control

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Introduction:

Telmisartan 40mg + Chlorthalidone 6.25mg is a low-dose, fixed-dose combination (FDC) antihypertensive designed to provide gentle but effective blood pressure control. This formulation pairs Telmisartan, an angiotensin II receptor blocker (ARB), with a mild dose of Chlorthalidone, a thiazide-like diuretic. Ideal for patients initiating combination therapy or those with mild to moderate hypertension, this tablet offers synergistic effects with reduced risk of side effects.

It’s especially useful in patients who require volume reduction with vascular resistance control—achieving optimal outcomes with fewer pills and better compliance.

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Mechanism of Action:

• Telmisartan 40mg blocks the action of angiotensin II at its receptor, leading to:

  • Vasodilation (relaxation of blood vessels)

  • Decreased aldosterone production

  • Reduced sodium and water retention

  • Lowered blood pressure and cardiovascular risk

• Chlorthalidone 6.25mg works at the distal renal tubules to:

  • Promote sodium and water excretion

  • Reduce blood volume

  • Lower peripheral vascular resistance

  • Provide a long half-life (up to 72 hours) for extended antihypertensive effect

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Therapeutic Indications:

• Essential hypertension

• Stage 1 and 2 hypertension, especially when monotherapy is insufficient

• Hypertension in elderly patients or those at cardiovascular risk

• Can be used as initial therapy or step-up therapy from monotherapy

• Kidney-friendly with proper monitoring, especially in diabetic hypertensives

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Dosage and Administration:

• Typically taken once daily, preferably in the morning

• May be taken with or without food

• Should be swallowed whole with water

• Dose may be adjusted based on patient response and clinical assessment

• Avoid dehydration, especially during hot weather or exercise

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Key Benefits:

• Combines vascular relaxation with gentle diuresis

• Once-daily dosing improves adherence

• Low-dose diuretic minimizes electrolyte imbalances

• Telmisartan’s cardio-renal protective effects support long-term health

• Reduces risk of stroke, heart attack, and kidney disease progression

• Suitable for elderly and salt-sensitive hypertensive patients

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Common Side Effects:

• Dizziness or lightheadedness

• Increased urination (usually transient)

• Weakness or fatigue

• Mild muscle cramps

• Headache

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Serious (Rare) Side Effects:

• Electrolyte disturbances (hypokalemia, hyponatremia)

• Hypotension (especially in volume-depleted patients)

• Renal function changes (monitoring advised)

• Hyperuricemia or gout (less common at 6.25mg Chlorthalidone dose)

• Allergic reactions or rash

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Precautions:

• Not recommended in pregnancy or lactation

• Caution in patients with renal impairment, gout, or electrolyte imbalance

• Monitor serum potassium, sodium, and kidney function periodically

• Avoid other potassium-sparing agents unless supervised

• Alcohol may intensify the blood pressure-lowering effect

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Storage Instructions:

• Store at 15–30°C in a dry, cool place

• Keep out of reach of children

• Protect from light and moisture

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Conclusion:

Telmisartan 40mg + Chlorthalidone 6.25mg is a well-balanced, effective combination for managing mild to moderate hypertension, offering a blend of vascular protection and gentle diuresis. Its low-dose profile reduces side effects while maintaining 24-hour blood pressure control, making it a preferred choice for early-stage or elderly hypertensive patients.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.