TENOHEP TABLET

🧬🛡️💊 Tenofovir Disoproxil Fumarate 300mg: Powerful Antiviral for HIV & Hepatitis B Control

Tenofovir Disoproxil Fumarate (TDF) 300mg is a potent antiviral medication belonging to the class of nucleotide reverse transcriptase inhibitors (NRTIs). It is primarily used in the treatment of HIV-1 infection and chronic hepatitis B virus (HBV). By inhibiting viral replication, Tenofovir helps reduce viral load, delay disease progression, and improve immune function in people living with HIV or HBV.

TDF is a backbone drug in many antiretroviral therapy (ART) regimens and is often combined with other antiviral agents for optimal efficacy.

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🔬 Mechanism of Action

Tenofovir Disoproxil Fumarate is a prodrug, which converts into tenofovir in the body. It mimics the natural building blocks of viral DNA and works by:

• Inhibiting reverse transcriptase enzyme in HIV

• Blocking HBV DNA polymerase in hepatitis B

• Preventing the virus from multiplying and spreading in the body

It does not cure HIV or hepatitis B, but significantly controls the viral load, helping to maintain better immune health and reduce the risk of transmission.

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📌 Indications and Uses

Tenofovir 300mg is prescribed for:

🔹 HIV-1 Infection

• In combination with other antiretroviral agents for adults and adolescents ≥12 years

• Reduces HIV RNA levels and improves CD4 cell count

🔹 Chronic Hepatitis B

• Monotherapy or in combination for treating active HBV infection

• Reduces hepatic inflammation and slows progression to cirrhosis or liver cancer

🔹 Pre-Exposure Prophylaxis (PrEP) (in combination with emtricitabine)

• For individuals at high risk of HIV infection

• Helps prevent HIV transmission before exposure

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💊 Dosage and Administration

• Usual dose: 300mg once daily, with or without food

• Dose adjustments required in renal impairment

• Must be used continuously, as prescribed; abrupt discontinuation may worsen hepatitis B

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⚠️ Precautions and Warnings

• Monitor renal function, especially in long-term therapy

• Use cautiously in patients with:

  • Osteoporosis or bone problems (may reduce bone mineral density)

  • Liver disease

  • Hepatitis B coinfection

• May cause lactic acidosis or severe hepatomegaly with steatosis (rare but serious)

Discontinuing Tenofovir in HBV patients may lead to severe flare-ups of hepatitis.

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🤒 Side Effects

Common:

• Nausea

• Diarrhea

• Headache

• Fatigue

• Abdominal pain

Serious:

• Kidney damage or failure

• Bone thinning (osteopenia, osteoporosis)

• Lactic acidosis (muscle pain, shortness of breath, weakness)

• Hepatic toxicity

Report any signs of weakness, bone pain, confusion, or yellowing of the eyes/skin to a doctor.

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🔄 Drug Interactions

• Use cautiously with:

  • NSAIDs (may worsen kidney effects)

  • Didanosine (increased risk of toxicity)

  • Other nephrotoxic drugs

Always inform your healthcare provider of all medications, including supplements.

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🧊 Storage Instructions

• Store at 20–25°C, away from moisture and heat

• Keep in original packaging

• Keep out of reach of children

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📝 Conclusion

Tenofovir Disoproxil Fumarate 300mg is a cornerstone in modern antiviral therapy, offering reliable suppression of HIV and hepatitis B viruses. With once-daily dosing, strong antiviral potency, and proven long-term benefits, it plays a vital role in improving viral control, immune function, and patient quality of life. Regular monitoring ensures safety and maximizes its life-saving potential.

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Always follow your doctor’s advice, dosage instructions, and never self-medicate.